Circulating Soluble Receptor Activator of Nuclear Factor-kappa B Ligand and C-C Motif Ligand-3 Correlate with Survival in Patients with Waldenstr öm’s Macroglobulinemia

Serum nuclear receptor ligand kappa B (sRANKL) and chemokine (C-C) motif ligand-3 (CCL-3) have been reported to be elevated in Waldenstr öm’s macroglobulinemia (WM) patients. However, there are no published data regarding the prognostic value of these molecules in WM, regarding progression free survival (PFS) and overall survival (OS). To evaluate the effect of these markers of bone remodeling on survival parameters we evaluated p rospectively serum cytokines and biological markers in 55 patients with symptomatic WM, before receiving any kind of treatment.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research