5-Fluorouracil enhances Protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: A mechanism-based clinical trial.

CONCLUSIONS: Serial 5FU and PDT improves AK clearance by at least two mechanisms, enhanced photosensitizer accumulation and p53 induction. Because 5FU and PDT are FDA-approved modalities, the combined regimen can be readily employed in clinical practice to reduce AK burden and reduce SCC risk. ClinicalTrials.gov NCT01525329. PMID: 29593028 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29593028?dopt=Abstract

Source: Clinical Cancer Research - March 28, 2018 Category: Cancer & Oncology Authors: Maytin EV, Anand S, Riha M, Lohser S, Tellez A, Ishak R, Karpinski L, Sot J, Hu B, Denisyuk A, Davis SC, Kyei A, Vidimos A Tags: Clin Cancer Res Source Type: research