Effects of Cryotherapy on Paclitaxel-Induced Neuropathy Effects of Cryotherapy on Paclitaxel-Induced Neuropathy
Wearing frozen flexible gloves and socks during infusion may reduce symptoms of paclitaxel-induced peripheral neuropathy.Journal of the National Cancer Institute
This article synthesizes the literature on efficacy and tolerability of extremity cryotherapy during taxane administration to identify if it is an intervention that can be provided to patients to mitigate these symptoms. METHODS: A literature review was performed using PubMed®, the Cochrane Database of Systematic Reviews, Ovid, Web of Science, and CINAHL®. 46 articles were initially identified, and 10 articles were reviewed (5 related to nail changes and 5 related to neuropathy). FINDINGS: Larger, powered studies are needed on these topics; however, existing data suggest this intervention as a promising l...
ConclusionsStrategies to prevent painful peripheral neuropathy are urgently needed. In this current trial, dropout due to discomfort precluded adequate power to fully understand the potential benefits of cryotherapy. Much more research is needed to discover safe and effective preventive strategies that can be easily implemented within busy infusion centers.
Condition: Breast Cancer Interventions: Device: Elasto-Gel™; Drug: Paclitaxel Sponsors: National Cancer Centre, Singapore; Terry Fox Foundation; Duke-NUS Academic Medicine Research Institute; Singapore General Hospital Recruiting
Breast cancer patients on paclitaxel had lower incidence of peripheral neuropathy with cryotherapy
Cryotherapy delivered to the hands and feet during weekly paclitaxel chemotherapy significantly reduces the incidence of peripheral neuropathy in patients with breast cancer.Medscape Medical News
The world's most celebrated athlete standing on the podium in Rio in honor of receiving yet another gold medal has something important in common with your lazy uncle throwing back a cold one in his Barcalounger. Yes, swimming powerhouse Michael Phelps, purple-spotted from cupping therapy, and your slovenly relative with a beer gut both share a bond -- a weakness in succumbing to the allure of voodoo medicine. Modern-day snake oil salesmen hawking quick cures and TV doctors peddling the latest diet miracle with blatantly ridiculous claims are everywhere on the tube, social media, the supermarket and old-fashioned billboards...
Conditions: Chemotherapeutic Agent Toxicity; Pain; Peripheral Neuropathy; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Therapy-related ToxicityInterventions: Procedure: cryotherapy; Other: questionnaire administration; Pr...