Soaring Cost of Cancer Therapy: Moving Beyond Sticker Shock Soaring Cost of Cancer Therapy: Moving Beyond Sticker Shock

State experiments with drug pricing may help reform the high-cost of cancer care.Journal of Clinical Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

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High-glucose promotes proliferation of human bladder cancer T24 cells by activating Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2018 Dec;22(23):8151-8160 Authors: Gao L, Xu FM, Shi WJ, Zhang S, Lu YL, Zhao DK, Long YF, Teng RB, Ge B Abstract OBJECTIVE: Bladder cancer is the most prevalent genitourinary malignant disorder worldwide. We aimed to observe effects of high-glucose on bladder cancer proliferation and explore the associated mechanisms. MATERIALS AND METHODS: Human bladder cancer cell line, T24, was divided into Blank, Control (Ctrl), 10 mmol/l, 20 mmol/l and 30 mmol/l ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Fortunately>80% of children diagnosed with cancer become long-term survivors; however, this population is at a significantly increased risk of morbidity and mortality as a result of their previous cancer therapy, and long-term follow-up (LTFU) is critical. Multiple barriers to receiving adequate LTFU care have been studied. We investigated whether lack of enrollment in a therapeutic clinical trial may be a barrier to receiving LTFU care. We conducted a review of 353 patient records at the Children’s Hospital of Michigan enrolled in our Children’s Oncology Group registry between January 1, 2005 and December 3...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
ConclusionsDependent on dose, RSV activated either anti-fibrotic or pro-fibrotic effects in kidneys. The risk of RSV consumption in individuals with impaired kidney function should be carefully considered.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
The National Cancer Institute in Rockville, Maryland, has opened an innovative clinical trial for patients with peritoneal mesothelioma that will explore the safety and effectiveness of a novel CAR T-cell therapy. The phase I trial also is being conducted at Washington University in St. Louis. It is aimed at patients whose disease has relapsed after initial chemotherapy treatment. It involves a laboratory modification of a patient’s T cells — a type of white blood cell — that can help the immune system kill the cancer. CAR T-cell therapy is a form of gene therapy that has been highly successful with blood...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
AbstractThe androgen-directed treatment of prostate cancer (PCa) is fraught with the recurrent profile of failed treatment due to drug resistance and must be addressed if we are to provide an effective therapeutic option. The most singular difficulty in the treatment of PCa is the failure to respond to classical androgen withdrawal or androgen blockade therapy, which often develops as the malignancy incurs genetic alterations and gain-of-function somatic mutations in the androgen receptor (AR). Physical cellular damaging therapeutic agents, such as radiation or activatable heat-generating transducers would circumvent class...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
Abstract Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. CDs a...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
New J. Chem., 2019,43,217-229 DOI: 10.1039/C8NJ03350A, PaperDipranjan Laha, Kunal Pal, Angshuman Ray Chowdhuri, Pravat Kumar Parida, Sumanta Kumar Sahu, Kuladip Jana, Parimal Karmakar Curcumin has shown therapeutic activity against triple-negative breast cancer (TNBC) cells, but it shows low efficacy and low bioavailability when administered as a free drug. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00924
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
SummaryPolymeric cyclodextrin –based nanoparticles are currently undergoing clinical trials as nanotherapeutics. Using a non-covalent approach, we decorated two cross-linked cyclodextrin polymers of different molecular weights with an RGD peptide derivative to construct a novel carrier for the targeted delivery of doxorubicin. RGD is the binding sequence for the integrin receptor family that is highly expressed in tumour tissues. The assembled host–guest systems were investigated using NMR and DLS techniques. We found that, in comparison with free doxorubicin or the binary complex doxorubicin/cyclodextrin polym...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Authors: Christensen JF, Simonsen C, Hojman P Abstract Exercise training is playing an increasing role in cancer care, as accumulating evidence demonstrates that exercise may prevent cancer, control disease progression, interact with anti-cancer therapies, and improve physical functioning and psychosocial outcomes. In this overview article, we present the current state of the field of exercise oncology, which currently comprises of nearly 700 unique exercise intervention trials with more than 50,000 cancer patients. First, we summarize the range of these interventions with regard to diagnoses, clinical setting, tim...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
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