Response to Letter About Memory and Brain Effects of Curcumin

Considerable disagreement exists on the necessity and extent of adjustment for multiple comparisons (1). Although many articles have discussed when and how to control for inflation of Type 1 errors (i.e., finding a difference between groups when none exists), there is no consensus in the literature regarding this issue (2-4). However, it has been pointed out that adjustment is not required when the research is addressing novel or exploratory hypotheses, when one also needs to consider the risk of making a Type 2 error (i.e., finding no difference when one exists) (2, 5).
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research