Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2  years after Roux-en-Y gastric bypass

Conclusions/interpretationFor up to 2  years following RYGB, obese participants without diabetes showed improvements in DI that approach population norms. Those with type 2 diabetes recovered islet-cell insulin secretion response yet continued to manifest abnormal insulin processing, with DI values that remained well below population n orms. These data suggest that, rather than waiting for lifestyle or medical failure, RYGB is ideally considered before, or as soon as possible after, onset of type 2 diabetes.Trial registrationClinicalTrials.gov NCT00433810
Source: Diabetologia - Category: Endocrinology Source Type: research