Mesothelioma Clinical Trial Evaluating Selecta ’ s SEL-403 Begins

A clinical trial testing a new therapeutic modality on patients with pleural and peritoneal mesothelioma is officially underway. Selecta Biosciences, a clinical-stage biopharmaceutical company, and the National Cancer Institute (NCI) teamed up for the phase 1 clinical trial under the Cooperative Research and Development Agreement. The trial will evaluate safety and tolerability of SEL-403, Selecta’s investigational new drug combination consisting of a potent anti-tumor agent (LMB-100) and a drug that prevents an immune response (SVP-Rapamycin). LMB-100 and SVP-Rapamycin have been studied separately in clinical trials. Researchers hope combining the two therapies will improve effectiveness and increase the number of treatments patients can receive before there is an antibody response and the LMB-100 portion stops working. The U.S. Food and Drug Administration accepted an investigational new drug application for SEL-403 in January. “Mesothelioma remains one of the deadliest and most challenging-to-treat forms of cancer,” Dr. Raffit Hassan, principal investigator of the trial and senior investigator at NCI’s Center for Cancer Research, said in a press release. “We are pleased to get this clinical investigation underway to determine if patients may indeed benefit from a combination therapy consisting of LMB-100 and SVP-Rapamycin.” Patent No. 1 Seeing Side Effects, Waiting for Results Jim McWhorter, who was diagnosed with pleural mesothelioma in May 2016, i...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news