Low - Dose Abiraterone Acetate Noninferior for Prostate Cancer
Low - dose AA with low - fat breakfast had greater effect on PSA; similar effect to standard dose
Black men with nonmetastatic prostate cancer did not appear more likely to die from this disease than white men when given similar access to care and standardized treatment, an analysis found.Medscape Medical News
ConclusionWe generated a second-generation CAR targeting either Lewis Y or GRP-78 with a truncated CD34-tag for purification. Because the differentiation and phenotype of the CAR-T product may have a critical impact on the post-infusion antitumor effect and persistence of the cells, we also investigated the phenotype of CAR-T product with different γc cytokines, i.e. IL-2, IL-7 and IL-15, to generate early differentiation stage cells with less exhaustion phenotypes. In the optimized protocol, by using the retroviral transduction system, starting from 3 × 107 PBMC, we're now able to produce approximately 109...
In conclusion, these results suggest that the health-care system in Nordland County successfully delivers state-of-the-art oncology care to patients with mPC. PMID: 31120400 [PubMed - in process]
ConclusionsIn patients with at least one negative PB, mpMRI + COG-TB sequence improves 3.5 (OR = 3.49) times the diagnosis prostate vs. ClTB.ResumenIntroducciónEl objetivo es comparar el rendimiento de la secuencia resonancia magnética (RM) y biopsia transrectal «cognitiva» (BTRCog) frente a la biopsia transrectal clásica (BTRCl) en pacientes con al menos una biopsia de próstata (BP) negativa.Material y métodoAnálisis retrospectivo de 205 pacientes con al menos una BP negativa. A 144 (70,2%) pacientes se les realizó antes de la biopsia una RM ...
CONCLUSIONS: The findings of this study suggested that the down-regulation of DUXAP10 expression suppressed the progression of prostate cancer by inhibiting cell proliferation, migration and promote cell apoptosis. PMID: 31114994 [PubMed - in process]
CONCLUSIONS: The current results further enhanced our understanding of the effects of LINC00662 in PCa and may help to provide a new potential target for PCa treatment. PMID: 31114993 [PubMed - in process]
[Premium Times] A study has revealed that most men in Nigeria do not have knowledge of prostate cancer and have not been screened of the disease.
(University of Helsinki) A new study indicates that PSA, a prostate cancer marker, is one of the catalysts that activate vascular endothelial and lymphangiogenic growth factors which contribute to the spread of cancer.
Overall active surveillance rates are up for low-risk prostate cancer, though the increase is significantly smaller for black patients
Publication date: Available online 22 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): J.M. Cozar, I. Robles-Fernandez, A. Rodriguez-Martinez, I. Puche-Sanz, F. Vazquez-Alonso, J.A. Lorente, L.J. Martinez-Gonzalez, M.J. Alvarez-CuberoAbstractThere is an urged need of non-invasive biomarkers for the implementation of precision medicine. These biomarkers are required to these days for improving prostate cancer (PCa) screening, treatment or stratification in current clinical strategies. There are several commercial kits (Oncotype DX genomic prostate score®, Prolaris®, among others) that use gen...