Diagnosing IgA Vasculitis in the Active Duty Population: The Importance of Early Diagnosis and Proper Biopsy Site Selection.

Diagnosing IgA Vasculitis in the Active Duty Population: The Importance of Early Diagnosis and Proper Biopsy Site Selection. Mil Med. 2018 Mar 26;: Authors: Flood D, Barber B, Miletta NR Abstract Immunoglobulin A associated vasculitis (IgAV), formerly called Henoch-Schönlein purpura, is a small vessel vasculitis which typically presents with upper and lower extremity palpable purpura and abdominal pain. It is the most common vasculitis in children, and is less common in adults. However, newer evidence suggests the incidence within the adult population is higher than previously reported. This case study demonstrates an adult military recruit presenting with new onset IgAV shortly after basic training. He noted a preceding upper respiratory tract infection, which is a common finding in those presenting with IgAV. The diagnosis was made by clinical findings, histopathological results and direct immunofluorescence. Adults tend to develop more necrotic and bullous lesions when compared with children. This can skew histopathology and direct immunofluorescence. There is no clear consensus in current literature for whether to obtain lesional or perilesional biopsies. Such recommendations could be particularly advantageous for adults given the abnormal lesions. This case study addresses the incidence of IgAV within the adult population, diagnostic criteria, long-term sequalea of IgAV, and the importance of a proper biopsy sight when making the diagnosis. ...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Related Links:

Authors: Ronconi G, Salini S, Maccauro G, Mammucari M, Ferrara PE PMID: 32450681 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
BACKGROUND: Gastrointestinal (GI) disorders are ranked first amongst medical diseases as a trigger of requests for mental health counselling. Child abuse has been regarded as one of the main causes of the development of functional abdominal pain (FAP) in c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
In this report, we present a patient with a complex L3 burst fracture from a remote trauma s/p stabilization. Thirty-two years later, he developed progressive neck pain, upper extremity radiculopathy, dysesthesias, and clinical myelopathy (dropping objects, gait imbalance). An MRI demonstrated an expansile syrinx from C2-conus medullaris which previously had been unsuccessfully treated by fenestration. We offered a T1–2 laminectomy and placement of synringosubarachnoid shunt. In the associated video (Supplemental Digital Content 1, http://links.lww.com/CLINSPINE/A107), we demonstrate the step-by-step approach for thi...
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Surgical Technique Source Type: research
Conclusions: This meta-analysis provides evidence suggesting that CDA was superior to ACDF in terms of NDI score, SF-36 HSPC score, and low rate of secondary surgical procedures. Furthermore, no significant differences existed between the CDA group and the ACDF group in the neck pain visual analog scale score, arm pain visual analog scale score, the rate of neurological success, adjacent segment degeneration, and adverse events. Level of Evidence: Level 1.
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Systematic Review Source Type: research
Study Design: A retrospective study using prospectively collected registry data. Objective: Examine the influence of preoperative mental health on outcomes after Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF). Summary of Background Data: Prior studies investigating the relationship between mental health and outcomes after lumbar spine surgery included small cohorts with short follow-up and heterogenous fusion techniques. The effect of MIS-TLIF on mental health also remains unclear. Methods: Prospectively collected registry data of 226 patients who underwent single-level MIS-TLIF at a single...
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
Study Design: A retrospective review of prospectively collected registry data. Objectives: (1) Examine functional outcomes of patients with postoperative sacral slope (SS)
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
From social media addiction to the discovery of musical genius – is the alleviation of boredom what really drives the world?´╗┐According to the great proto-existentialist philosopher Arthur Schopenhauer, the life of a human or other beast “swings like a pendulum back and forth between pain and boredom”. Indeed, pain (or want) and boredom are the two main constituents of existence, and not only during the lockdown pha se of a pandemic – a thought that might (or might not) afford some gloomy relief to many right now.Schopenhauer was arguably the first western philosopher to take boredom seriously as o...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Society books Philosophy books Psychology Culture Source Type: news
This article discusses available interventions for patients with cancer pain.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: Review Article Source Type: research
This study evaluated the efficacy and safety of baricitinib, an oral Janus kinase (JAK)1/JAK2 inhibitor, in patients with moderately to severely active rheumatoid arthritis (RA) and inadequate response to methotrexate (MTX) therapy. METHODS: In this phase 3, double-blind, 52-week, placebo-controlled study, 290 patients with moderately to severely active RA and inadequate response to MTX were randomly assigned 1:1 to placebo or baricitinib 4-mg once daily, stratified by country (China, Brazil, Argentina) and presence of joint erosions. Primary endpoint measures included American College of Rheumatology 20% response (ACR...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Conclusions: No standardized methods of diagnosis or treatment were identifiable. These findings highlight the need for standardization of the diagnosis and treatment of PID attributed to chlamydial and gonococcal infections. PMID: 32454581 [PubMed - in process]
Source: Infectious Diseases in Obstetrics and Gynecology - Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research
More News: Children | Eyes | Henoch-Schonlein Purpura | Hypermetropia (long sighted) | International Medicine & Public Health | Pain | Respiratory Medicine | Study | Training | Universities & Medical Training | Vasculitis