Do treatment patterns alter beliefs cancer patients hold regarding oral oncolytic agents?
Psycho-Oncology,Volume 27, Issue 3, Page 1005-1012, March 2018.
AbstractBackgroundHypercoagulability is a major cancer-associated complication linked to poor patient prognosis. The production of neutrophil extracellular traps (NETs) is increasingly found to be linked with the development and metastasis of cancer, as well as with thrombi formation in cancer patients. We hypothesized that the neutrophil NET release may be triggered by specific cytokines in oral squamous cell carcinoma (OSCC) patients, thereby predisposing them to a hypercoagulable state. Moreover, we have evaluated the interaction between NETs and endothelial cells (ECs).MethodsNET procoagulant activity was assessed base...
Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other wellknown benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure. PMID: 31195790 [PubMed - as supplied by publisher]
CONCLUSIONS: At current costs, cabozantinib is not cost-effective for second-line therapy of HCC in the United States. PMID: 31200357 [PubMed - in process]
Brujavanol E (1), a new quassinoid derivative, along with four known quassinoids (2–5), were isolated from the leaves of Brucea javanica. The chemical structure was elucidated on the basis of extensive spectroscopic analysis. Compound1 showed significant antimalarial activity (against Plasmodium falciparum strain K1) and cytotoxicity activity against human oral epidermoid carcinoma cancer (KB) and human breast cancer (MCF-7) cell lines with IC50 values 5.54, 2.16, and 1.52 μM, respectively.
(ERA-EDTA) While a kidney transplant can restore healthy kidney function, recipients remain at increased risk of fractures, heart disease, diabetes and some cancers. The VITALE study shows that, compared with currently recommended doses, high doses of oral vitamin D? (cholecalciferol) lower the risk of fractures, but have no effect on the risks of heart disease, diabetes or cancer after a kidney transplant .
by Benjamin J. Huang, Anica M. Wandler, Lauren K. Meyer, Monique Dail, Anneleen Daemen, Deepak Sampath, Qing Li, Xinyue Wang, Jasmine C. Wong, Joy Nakitandwe, James R. Downing, Jinghui Zhang, Barry S. Taylor, Kevin Shannon The lack of predictive preclinical models is a fundamental barrier to translating knowledge about the molecular pathogenesis of cancer into improved therapies. Insertional mutagenesis (IM) in mice is a robust strategy for generating malignancies that recapitulate the extensive inter- and intra-tum oral genetic heterogeneity found in advanced human cancers. While the central role of "driver" vi...
Conclusion: In our study, we established a two-miRNA signature that was strongly and independently associated with prognosis in OSCC, and may serve as a promising prognosis predictor.
Conclusion: With a good imaging capability and anti-tumor efficacy, our NPs successfully outlined orthotopic tongue tumors and metastatic lymph nodes as well as enabled chemo-photothermal therapy combination. Our study established a solid foundation for the application of new clinical diagnosis and treatment patterns in the future.
Conclusions: Anticancer nanotherapies derived from intrinsic anti-inflammatory nanocarriers are promising for targeted combination treatment of inflammation-associated tumors by simultaneously shaping pro-inflammatory microenvironment toward a relatively normal niche sensitive to chemotherapy.
Conclusion: Our ferroptosis promoted PDT approach markedly enhances anticancer actions by relieving hypoxia and promoting ROS production, thereby our work provides a new approach for overcoming hypoxia-associated resistance of PDT in cancer treatment.