Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis

Catheterization and Cardiovascular Interventions,Volume 91, Issue 4, Page 820-826, March 1, 2018.
Source: Catheterization and Cardiovascular Interventions - Category: Cardiovascular & Thoracic Surgery Source Type: research

Related Links:

Increases in the number of cell therapies in the preclinical and clinical phases have prompted the need for reliable and noninvasive assays to validate transplant function in clinical biomanufacturing. We developed a robust characterization methodology composed of quantitative bright-field absorbance microscopy (QBAM) and deep neural networks (DNNs) to noninvasively predict tissue function and cellular donor identity. The methodology was validated using clinical-grade induced pluripotent stem cell–derived retinal pigment epithelial cells (iPSC-RPE). QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The advent of human induced pluripotent stem cells (iPSCs) provided a means for avoiding ethical concerns associated with the use of cells isolated from human embryos. The number of labs now using iPSCs to generate photoreceptor, retinal pigmented epithelial (RPE), and more recently choroidal endothelial cells has grown exponentially. However, for autologous cell replacement to be effective, manufacturing strategies will need to change. Many tasks carried out by hand will need simplifying and automating. In this issue of the JCI, Schaub and colleagues combined quantitative brightfield microscopy and artificial intelligence...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The recent article by Hicks et  al1 is very helpful in clarifying the long-standing debate concerning arteriovenous (AV) access ligation following successful kidney transplantation. The authors found that AV access ligation is uncommon in the United States, is not associated with post-transplantation allograft failure, and offer ed no reduction in all-cause mortality. They concluded that AV access ligation should be reserved for access-related complications, such as dialysis access-associated hand ischemia.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Authors: Park CH, Kim MJ, Yang CY, Yokozawa T, Shin YS Abstract Safflower seed is effective against oxidative stress, mediating the activation of the apoptotic signaling pathway in the renal tissues of cisplatin-treated mice. The anticancer activity of safflower in various cancer cell lines has also been reported. The present study was conducted to evaluate the potential synergistic anticancer effects of the co-treatment of safflower seed extracts and cisplatin in RKO cells and in BALB/c mice bearing RKO cell-derived human colorectal tumors. In the cellular system, RKO cells were treated with safflower seed extract...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
We describe a case of successful combined management of BPAF using both bronchial and pulmonary stent placement.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 21 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Roberto V.P. Ribeiro, Jan O. Friedrich, Maral Ouzounian, Terrance Yau, Jessica Lee, Bobby Yanagawa, Canadian Cardiovascular Surgery Meta-Analysis Working GroupBackgroundThe optimal donor heart preservation and management strategy during heart transplantation remains controversial. Here, we perform a systematic review and meta-analysis of the effect of supplemental cardioplegia administration during donor heart implant for transplantation.MethodsWe searched MEDLINE and EMBASE databases until February 2019 for studies comparing...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion:Our findings demonstrate that rTMS treatment and hMSC transplantation could synergistically create a favorable microenvironment for cell survival within the PD rat brain, through alteration of soluble factors such as neurotrophic/growth factors and anti-/pro-inflammatory cytokines related to neuronal protection or repair, with preservation of DA neurons and improvement of motor functions.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
2003 to 2017 saw reduction in nonrelapse mortality, relapse of cancer, relapse - related and overall mortality
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Oncology, Pathology, Journal, Source Type: news
Around 850 million people currently are affected by different types of kidney disorders.1 Up to 1 in 10 adults worldwide has chronic kidney disease (CKD), which is invariably irreversible and mostly progressive. The global burden of CKD is increasing, and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.2 If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease, CKD progresses to end-stage kidney disease, where life cannot be sustained without dialysis therapy or kidney transplantation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Editorial Source Type: research
A 72-year-old man was admitted to the hospital with diabetic ketoacidosis and acute kidney injury 3 months after receiving a deceased-donor kidney transplant. He had undergone induction immunosuppression with rabbit-antithymocyte globulin and took tacrolimus and mycophenolic acid for maintenance immunosuppression. Twelve days prior to admission to the hospital, right knee pain and swelling developed. Synovial fluid was aspirated and showed a white blood cell count of 1825, 61% polymorphonuclear neutrophils, and monosodium urate crystals visualized by polarizing light microscopy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
More News: Cardiology | Cardiovascular | Heart | Transplants