Pregnancy management and outcome in patients with four different tetrahydrobiopterin disorders

ConclusionAlthough our data on 16 pregnancies in seven patients did not  present any association of standard drug treatment with an increased rate of pregnancy complications, abnormal obstetrical or paediatric outcome, an intensive clinical and biochemical supervision by a multidisciplinary team before, during and after the pregnancy in any BH4 deficiency is essential since available data on pregnancies in patients with BH4 deficiencies is limited.
Source: Journal of Inherited Metabolic Disease - Category: Internal Medicine Source Type: research