4,000 Eggs and Embryos Are Lost in Tank Failure, Ohio Fertility Clinic Says
The clinic said about 950 patients were affected by the problem with the storage tank this month, in which the tank ’ s temperature rose and an alarm did not go off.
CONCLUSION: First line management of infertility once a diagnosis of PCOS is made should include weight loss and exercise with goals to below class 2 obesity (BMI
In this study we report on the investigation of complete infertility in a 5-year-old Thoroughbred stallion. The stallion was considered infertile after performing 72 covers and achieving 0 pregnancies over one breeding season. Although initial semen assessment (sperm concentration, motility, longevity and morphology) revealed below average parameters, these were not sufficient to explain complete infertility under a managed system. The stallion displayed normal libido, breeding behavior and ejaculation, and semen contained viable, progressively motile spermatozoa (number of total progressively motile sperm per ejaculate ra...
Seminal vesiculitis is one of the causes of pyospermia affecting the fertility of stallions. To date, recommended treatments have variable results and reoccurrence is a common sequela. The development of management tools for stallions affected is warranted. Thus, the objective of this study was to evaluate fractionated semen collection as a method to rescue fertility of stallions diagnosed with seminal vesiculitis. The study was performed from April of 2014 to October of 2017 with six light-breed stallions with a history of infertility and pyospermia.
The imbalance between reactive oxygen species (ROS) generation and antioxidant defensive mechanisms results in excessive ROS levels that promote sperm DNA fragmentation, mitochondrial dysfunction and membrane lipid peroxidation, which are associated with infertility. Curcumin (CUR, Curcuma longa) is a natural phytochemical compound of turmeric that exhibits antioxidant properties. CUR can have beneficial effect on sperm motility by increasing antioxidant mechanisms and controlling lipid peroxidation and nitric oxide production.
Low levels of intracellular reactive oxygen species (ROS) are essential for normal spermatozoal function and are produced by sperm mitochondria as a byproduct of metabolism, but in excess, ROS can cause catastrophic cellular damage and has been correlated with infertility, poor sperm motility and abnormal morphologies in humans (Aziz et. al. Fertility and Sterility. 2004; 2: 349-354). Stallion sperm fuel motility predominantly by oxidative phosphorylation-produced ATP, requiring high basal rates of mitochondrial function.
While it is well established that mammalian male fertility has a genetic component, genomics tools for evaluating fertility in stallions are limited. The Y chromosome is enriched with genes important for spermatogenesis and sperm functions as evidenced by human and mouse studies showing causative links between Y chromosome rearrangements, mutations, copy number variants (CNVs) and various male infertility phenotypes; hence, Y chromosome studies were initiated in the horse. We recently produced a 9.5 Mb annotated reference sequence for the male specific region of the horse Y (MSY).
Oxidative stress induced by reactive oxygen species (ROS) is a major cause of male infertility. The sperm plasma membrane is vulnerable to oxidative stress being rich in polyunsaturated fatty acids. Equine spermatozoa appear relatively more resistant to membrane peroxidation than sperm of other domestic animals; however, cryopreservation increases susceptibility to lipid peroxidation . The effects of oxidative stress are particularly important during sperm storage, and damage is further increased when sperm are separated from the seminal plasma, which contains much of the antioxidant capacity.
Granulosa cell tumours (GCT) are the most common tumor which affect ovarian tissue in mares. Mares with GCT may become infertile due to the suppressed activity of the contralateral normal ovary, and if GCT are ablated by surgery, the normal ovary will become active, with recovery from infertility .
Authors: Özkan ZS, Deveci D, Akpolat N, İlhan F, Şimşek M, Timurkan H Abstract Background/aim: To investigate the possible differences in endometrial leukocyte subtype distribution between women with unexplained infertility and normal fertile women and to determine whether there is a correlation between endometrial leukocyte counts and plasma cytokine levels in unexplained infertility. Materials and methods: This case-control study involved 79 infertile and 40 fertile women. Peripheral venous blood samples and endometrial samples were obtained on day 21 of the menstrual cycle. Plasma interleukin-4 (IL4), IL...
Conclusion KGC04P attenuated heat stress-induced testicular damage by a multi-functional approach and can be developed as an excellent therapeutic agent for hyperthermia-mediated male infertility.