An Interesting Programmed Aging View on Telomerase and the Epigenetic Clock

The author noted here sees aging as programmed, in the sense that it is an epigenetic program selected for by evolution because shorter life spans prevent population-level ecological issues. His writing is usually a good illustration of how this concept of aging as a selected epigenetic program leads to very different conclusions on the nature of aging as a whole, as well as on any specific research result. In the case of this post, the topic is the role of telomere length and telomerase in aging, and their relationship to the established DNA methylation biomarkers of aging. The mainstream view of epigenetic change with age is that it is a reaction to accumulated cell and tissue damage, one that evolved in the limited selection pressure thought to characterize post-reproductive life span. Both damage and epigenetic changes are components of a decline that is an accidental outcome of the aggressive selection for success in early life. Evolution produces biological systems that do well initially, then corrode and fail in a haphazard fashion, because there was no selection for long-term function. Thus systems that generate damage as a side-effect of normal operation, and systems that have limited capacity that fills up and causes issues in later life are found everywhere in our biology. The debate over programmed versus non-programmed aging, and the ordering of cause and effect between cell and tissue damage versus epigenetic change, will be settled over the next d...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

Related Links:

Publication date: Available online 7 August 2019Source: SexologiesAuthor(s): M. OhayonRésuméL’évolution du pronostic de l’infection par le VIH et l’impact des stratégies biomédicales sur la prévention de la transmission ont renforcé la singularité de la situation des hommes vivant avec le VIH à l’intérieur des minorités homosexuelles. Au fur et à mesure que la question des devoirs, centrés sur la prévention, glissait vers celle du pouvoir, le séropositif, héros martyr des années 198...
Source: Sexologies - Category: Sexual Medicine Source Type: research
This report describes the results of workplace absenteeism surveillance analyses conducted during the high-severity 2017-18 influenza season (October 2017-September 2018) (4). Absenteeism increased sharply in November, peaked in January and, at its peak, was significantly higher than the average during the previous five seasons. Persons especially affected included male workers, workers aged 45-64 years, workers living in U.S. Department of Health and Human Services (HHS) Region 6* and Region 9,† and those working in management, business, and financial; installation, maintenance, and repair; and production and relat...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Abstract Type 2 Diabetes Mellitus (T2DM) is reaching epidemic levels worldwide and with it, there is a significant increase in complications associated with the disease. T2DM affects virtually all organ systems including the eye. While frequently overlooked, diabetic keratopathy is the most common ocular complication of diabetes and can manifest in mild to severe forms, the latter of which poses a major threat to vision. As the initial barrier between the environment and the eye, the corneal epithelium functions in innate immune defense. Compromise of this barrier may predispose the cornea to infection and can hin...
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research
Publication date: Available online 8 June 2019Source: SexologiesAuthor(s): M. OhayonSummaryImprovements in the prognosis for HIV infection and the impact of biomedical strategies for the prevention of transmission have created very specific situations for men who live with HIV within the homosexual minorities. Originally focused on their duty in preventing transmission, the issue at stake gradually moved towards one of power, with the HIV-infected person, the hero/martyr of the 1980s and 1990s, becoming the hero who has vanquished the fear of Aids. Undetectable viral load, the standard of current treatment, makes the indiv...
Source: Sexologies - Category: Sexual Medicine Source Type: research
Publication date: Available online 8 June 2019Source: SexologiesAuthor(s): M. OhayonSummaryImprovements in the prognosis for HIV infection and the impact of biomedical strategies for the prevention of transmission have created very specific situations for men who live with HIV within the homosexual minorities. Originally focused on their duty in preventing transmission, the issue at stake gradually moved towards one of power, with the HIV-infected person, the hero/martyr of the 1980s and 1990s, becoming the hero who has vanquished the fear of Aids. Undetectable viral load, the standard of current treatment, makes the indiv...
Source: Sexologies - Category: Sexual Medicine Source Type: research
Update 26th April – Doctors of the World teams are currently monitoring the impact of Cyclone Kenneth and will provide support if needed. John Segredo Accommodation Centre is a makeshift camp set up for those displaced by Cyclone Idai.   100 km from the port city of Beira, the camp is currently housing thousands of people. There are serious concerns about the source of drinking water,which is located many miles away and was significantly damaged by the passing storm, and food is currently rationed. “We help repair and equip local health centers so that they can resume operations. At the same time, we are ...
Source: Doctors of the World News - Category: International Medicine & Public Health Authors: Tags: Uncategorised Source Type: news
Ali Mahzari1, Songpei Li1, Xiu Zhou1,2, Dongli Li2, Sherouk Fouda1, Majid Alhomrani1, Wala Alzahrani1, Stephen R. Robinson1 and Ji-Ming Ye1,2* 1Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia 2School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NAS...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we infected pregnant first parity gilts in their first, second and third trimesters of gestation with PEDV to determine the impact of stage of gestation on generation of maternal B-cell immunity, the gut-MG-sIgA axis and lactogenic immune protection in PEDV challenged piglets. Our goal was to identify innate and adaptive immune factors during pregnancy that influence lymphocyte trafficking, in addition to immune correlates of lactogenic immune protection in neonatal suckling piglets. Understanding the impact of stage of gestation at PEDV infection or exposure on maternal immunity will allow more precise mate...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge Attila Fintha1, Ákos Gasparics2, László Rosivall3 and Attila Sebe3,4* 12nd Department of Pathology, Semmelweis University, Budapest, Hungary 21st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary 3Department of Pathophysiology, International Nephrology Research and Training Center, Semmelweis University, Budapest, Hungary 4Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany Back in 1995, a landmark paper was published, which shaped the fi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Given the opposing pressures placed on dermatologists and dermatologic surgeons by the need for adequate postoperative analgesia and the current US opioid epidemic, a systematic review was performed to analyze postoperative pain management in outpatient dermatologic surgery. Dermatologic procedures are generally associated with minor postoperative pain of short duration. Anxiety reduction may lead to less postoperative pain. Studies vary on which anatomic locations and repair types are more or less associated with pain. Evidence supports the use of acetaminophen and ibuprofen for first-line postoperative analgesia in derma...
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research
More News: Biology | Epidemics | Epidemiology | Gastroschisis Repair | Genetics | Research | Statistics | Study