[Benign and malignant giant-cell rich lesions of bone: Pathological diagnosis with special emphasis on recent immunohistochemistry and molecular techniques].

[Benign and malignant giant-cell rich lesions of bone: Pathological diagnosis with special emphasis on recent immunohistochemistry and molecular techniques].
Ann Pathol. 2018 Mar 23;:
Authors: Macagno N, Caselles K, Aubert S, Audard V, Gomez-Brouchet A, Galant C, Guinebretière JM, Karanian M, Larousserie F, Marie B, de Pinieux G, Bouvier C
Abstract
The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Amongst malignant neoplasms, variants of conventional osteosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma and bone metastasis must be discussed. Recently, new diagnostic markers, antibodies for immuno-histochemistry and genetic markers, have been developed and are helpful to diagnose such lesions.
PMID: 29580573 [PubMed - as supplied by publisher]

Source: Annales de Pathologie - March 23, 2018 Category: Pathology Authors: Macagno N, Caselles K, Aubert S, Audard V, Gomez-Brouchet A, Galant C, Guinebretière JM, Karanian M, Larousserie F, Marie B, de Pinieux G, Bouvier C Tags: Ann Pathol Source Type: research