Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease

Conclusions: Our findings suggest that renal iron handling may be associated with megalin-mediated endo-lysosomal metabolic load in PTECs of residual nephrons and oxidative stress in renal tubules.Kidney Blood Press Res 2018;43:458 –470
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 13 November 2018Source: Journal of Critical CareAuthor(s): Toshiyuki Mizota, Li Dong, Chikashi Takeda, Atsuko Shiraki, Shino Matsukawa, Satoshi Shimizu, Shinichi KaiAbstractPurposeWe conducted a retrospective cohort study to determine incidences of transient and persistent acute kidney injury (AKI) after major abdominal surgery and their impacts on long-term outcome.Materials and methodsWe enrolled 3751 patients undergoing major abdominal surgery. Postoperative AKI was classified as transient or persistent based on the return of serum creatinine to the non-AKI range within 7 days post-s...
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
The loss of bone mineral density caused by Chronic Kidney Disease can make the delineation of a patient’s bony anatomy impossible during intra-operative fluoroscopy. This has the potential to increase the failure rate of implants used in the surgical treatment of neck of femur fractures due to sub-optimal placements. Intra-operative arthrograms add to the techniques available to a surgeon to achieve optimal implant placement without compromising the patient’s renal function nor increasing the radiation dose exposure to the surgical team.
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Tips and Pearls Source Type: research
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Tran Van Hung, Jun Wanatanbe, Yasunori Yonejima, Keiko Hisa, Yoshinari Yamamoto, Takuya SuzukiAbstractFeeding with 10% leucosaccharides for 3 weeks mitigated the development of adenine-induced chronic kidney disease in mice, as assessed by plasma urea, renal expression of inflammatory- and fibrosis-associated molecules, and colonic expression of tight junction proteins. Leucosaccharides are exopolysaccharides produced by Leuconostoc mesenteroides subsp. mesenteroides strain NTM048. Sequencing of 16S rRNA also revealed that leucosacchar...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Chronic kidney disease is an ongoing deterioration of renal function that often progresses to end-stage renal disease. Management goals in children include slowing disease progression, prevention and treatment of complications, and optimizing growth, development, and quality of life. Nutritional management is critically important to achieve these goals. Control of blood pressure, proteinuria, and metabolic acidosis with dietary and pharmacologic measures may slow progression of chronic kidney disease. Although significant progress in management has been made, further research is required to resolve many outstanding controv...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
This article describes the clinical presentation, laboratory evaluation, genetics, pathophysiology, management, and future therapies of Dent disease.
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicate...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
Obesity is a leading cause of chronic kidney disease. Children with severe obesity have an increased prevalence of early kidney abnormalities and are at high risk to develop kidney failure in adulthood. The pathophysiology of obesity-related kidney disease is incompletely understood, although the postulated mechanisms of kidney injury include hyperfiltration, adipokine dysregulation, and lipotoxic injury. An improved understanding of the long-term effects of obesity on kidney health is essential treat the growing epidemic of obesity-related kidney disease. The purpose of this article is to review the epidemiology, pathophy...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
AbstractBackgroundOn a global scale, type II diabetes mellitus (T2DM) remain a major health problem and it is the driver for chronic kidney disease (CKD). Despite this association, we still do not have sufficient biomarkers to anticipate better outcomes. N-glycosylation profiles are robust biomarkers and can be used for early monitoring of the progression of T2DM towards CKD.MethodsIn this cross-sectional study, we recruited 241 T2DM patients from January to May 2016. Demographic and anthropometric data were collected, following which fasting blood samples were collected for clinical analyses. Renal function decline was de...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Authors: Park S, Jeong TD Abstract The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation can be calculated according to race, sex, and creatinine concentration (subgroup equation) or in the form expressed by one equation (single equation). Minor differences in the constants used in the CKD-EPI equations (subgroup vs single equations) could result in a significant difference in the estimated glomerular filtration rate (eGFR). We evaluated the impact of this difference in 79,709 Korean patients. The eGFR was calculated as an integer using the single and subgroup CKD-EPI equations. ...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
Publication date: Available online 15 November 2018Source: Veterinary MicrobiologyAuthor(s): Kripitch Sutummaporn, Kazuhiko Suzuki, Noboru Machida, Tetsuya Mizutani, Eun-sil Park, Morikawa Shigeru, Tetsuya FuruyaAbstractFeline morbillivirus (FeMV) is an emerging member of morbillivirus discovered in 2012. Although association of FeMV infection with kidney diseases in cats has been suggested, the pathogenicity of the virus has not been clear to date. To study the association between FeMV infection and pathological changes in kidney tissues of infected cats, we performed immunohistochemistry and immunofluorescent assays to d...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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