miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells
• EKLF expression is down-regulated by miR-326 binding to the 3'UTR at the translational level.• miR-326 plays role in hemoglobin switching and erythroid differentiation via EKLF.• miR-326 expression is positively correlated with HbF levels in β-thalassemia major patients.
Source: Experimental Hematology - Category: Hematology Authors: Yihong Li, Dun Liu, Xinhua Zhang, Zhiming Li, Yuhua Ye, Qifa Liu, Jie Shen, Zhi Chen, Huajie Huang, Yunhao Liang, Xu Han, Jing Liu, Xiuli An, Narla Mohandas, Xiangmin Xu Source Type: research
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