miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells

• EKLF expression is down-regulated by miR-326 binding to the 3'UTR at the translational level.• miR-326 plays role in hemoglobin switching and erythroid differentiation via EKLF.• miR-326 expression is positively correlated with HbF levels in β-thalassemia major patients.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research
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