Nox2: a new challenge for antiplatelet treatment?

The functional interplay between reactive oxidant species (ROS) and platelet activation was originally demonstrated by Del Principe et al. [1], who used H2O2 as a stimulus to aggregate platelets. H2O2 –mediated platelet aggregation occurred via calcium mobilization and enhanced thromboxane(Tx) A2 biosynthesis, an effect blunted if platelets were incubated with catalase, an enzyme that destroys H2O2 [2]. The inhibitory effect of other antioxidants such as vitamin C and E confirmed intra-platelet redox status as an important factor modulating platelet aggregation(PA) [3].
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research

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