Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung.

Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung. Ann Thorac Surg. 2018 Apr;105(4):e145-e147 Authors: Wiener DC, Bravo-Iñiguez CE, Trien-Vihn Ho V, Qian X, Jaklitsch MT Abstract Donor T cells after allogeneic hematopoietic cell transplantation can give rise to the graft-versus-tumor (GVT) effect in hematologic malignancies. GVT effect has been reported previously to cause regression of some solid tumors. However, none have reported a documented case of GVT effect leading to complete resolution of adenocarcinoma of the lung. Here, we present the case of complete regression of a pathologically proven adenocarcinoma of the lung in a patient undergoing myeloablative-matched unrelated donor peripheral blood stem cell transplantation for the treatment of acute myelogenous leukemia. PMID: 29571344 [PubMed - in process]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research