Alzheimer's Stigma, Glenn Campbell, Pat Summitt

So there they were, Pat Summitt and Glen Campbell, sitting there and announcing to the world, I have Alzheimer's.By Bob DeMarcoAlzheimer's Reading RoomI think it is safe to say that a large fraction of the American public were greatly saddened by the news that both Pat Summitt and Glen Campbell have been diagnosed with probable Alzheimer's disease.I can tell you this. On the day when the news was released about Pat Summitt we had a record number of people coming to theAlzheimer's Reading Room via search looking for information on dementia. This continued for a few days.Two articles stood out,What is the Difference Between Alzheimer ’s and DementiaTest Your Memory for Alzheimer's and Dementia (5 Best Tests)What is the difference between Alzheimer's and dementia continues to be the number one search article on this website. With this in mind, you might want to share that article via email or social media with others.Subscribe to the Alzheimer's Reading - This is a Free Service - Join NowCurrent statistics indicate that more than half of the American population has been touched by Alzheimer's disease. This number rises each year, and it continues to rise fast.I think Dr Oz said it best on his television show last yearEveryone in the audience is either going to get Alzheimer's, or know someone who has it.The awareness of Alzheimer's certainly grew with the announcements that Pat Summitt and Glen Campbell are now living with Alzheimer's.I have been thinking about this f...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers announcement dementia Glen Campbell health life life news lifestyle Pat Summitt Source Type: blogs

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CONCLUSION: Increased levels of inflammatory markers were not associated with faster progression as measured by the annual change on the CDR-SB or MMSE score. PMID: 31414991 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
CONCLUSIONS: Scan recipients were willing to accept a treatment with a high risk of death. Discordance was affected by scan recipient's having poorer functioning. PMID: 31414990 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Mancuso R, Sicurella M, Agostini S, Marconi P, Clerici M Abstract Introduction: Alzheimer's disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the pathogenesis of the disease. Areas covered: We review the literature focusing on viral characteristics of HSV-1, the mechanisms this virus uses to infect neural cells, its interaction with the host immune system and genetic background and summarizes results and research that support the hypothesis of an ass...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
In this study, the effects ofAlpinia oxyphylla —Schisandra chinensis herb pair (ASHP) as well as its bioactive components on cognitive deficiency and dementia were revealed via A β1 –42-induced AD in mouse. Morris water maze test showed that acute administration of ASHP and SCH  + NKT treatments had higher discrimination index in the object recognition task, more quadrant dwell time and shorter escape latency compared with those in the Morris water maze. The levels of TNF-α, IL-1β and IL-6 were decreased after ASHP and SCH + NKT treatment. The inflammatory respon se w...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Conditions:   Alzheimer Dementia;   Caregiver;   Dementia Alzheimers Intervention:   Behavioral: Telephone-delivered Mindfulness Sponsors:   University of North Carolina, Chapel Hill;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThis is the first study suggesting that D-amino acids in blood may be correlated with ADAS-cog in different items and in the opposite direction. Lower D-glutamate and higher D-alanine levels may predict more behavioral symptoms. In summary, D-glutamate, d-serine and D-alanine play different and characteristic roles in AD. Further longitudinal studies are warranted to elucidate the function and interaction of D-amino acids in specific cognitive domains as well as various phases of dementia.
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Conclusion: Blood transfusion, especially transfusion of any type of red blood cells is associated with an increased risk of dementia.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
The microtubule (MT)-associated protein tau regulates the critical growing and shortening behaviors of MTs, and its normal activity is essential for neuronal development and maintenance. Accordingly, aberrant tau action is tightly associated with Alzheimer's disease and is genetically linked to several additional neurodegenerative diseases known as tauopathies. Although tau is known to promote net MT growth and stability, the precise mechanistic details governing its regulation of MT dynamics remain unclear. Here, we have used the slowly-hydrolyzable GTP analog, guanylyl-(α,β)-methylene-diphosphonate (GMPCPP), t...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Neurobiology Source Type: research
DISCUSSION: DCM is likely to be a cost-effective strategy in treating dementia and thus beneficial for public health-care payers and patients, especially for those living alone. PMID: 31409541 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed. RESULTS: FDG standardized uptake value ratio, eAV45 (0-2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H2O PET (regional Pearson r = 0.54-0.82, 0.70-0.94, and 0.65-0.92, respectively; P 
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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