Startup Turns to Liquified Silk for Tissue Regeneration
A Boston-area plastic surgery startup wants to use a reverse-engineered form of an ancient medical material in tissue regeneration for aesthetics and medical purposes. Sofregen is working on tissue regeneration using liquefied silk protein, which has emerged from academic research in recent decades. Liquefied silk protein offers biocompatibility and engineering controllability without using harsh chemicals, according to Sofregen chief medical officer Anh Hoang. Hear Anh Hoang discuss the use of silk protein in implantable devices on April 18, 2018, at BIOMEDevice Boston. Use promo code "MDDI" for 20% off conference registration and free expo access. “It’s already used in sutures and mesh,” Hoang said. “We can control how much protein content there is. We can control the mechanics of it.” Silk has been used in medical applications for about 2,000 years, but the first mass-produced, sterile silk sutures were invented by Johnson &Johnson in 1887. Working with technology developed at Tufts University and the University of Pittsburgh, Sofregen is developing a silk scaffold that can be injected to provide immediate bulking of tissue and eventually help it regenerate. It has applied for FDA approval. The first indication would be to bulk up vocal folds so they can come together to produce the sounds used for speech. After the initial bulking, the silk scaffold would be replaced by the patient’s own tissue over the course of 2...
POLLEN COUNT UK forecast: Hay fever patients are at risk of unwanted allergy symptoms today . Where are hay fever sufferers most likely to end up with signs of allergic rhinitis, including sneezing and runny noses?
Hey all, current 3rd year- soon to be 4th year. Im planning on going into internal medicine, and our current IM chair recommends that we do 5-6 audition rotations. I've heard mixed opinions on this and was thinking about foregoing them and pursuing elective rotations in different IM subspecialties (allergy, rheum, etc.) instead. I am a pretty average applicant (mid 220s step 1, 600 level 1, mostly passes). What do you guys think? I'm planning to apply pretty broadly.
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A recent study found climate change may be making things worse
Peanut allergy is a common IgE-mediated hypersensitivity that has no curative option. Allergen-specific immunotherapy (ASIT) has recently emerged as a promising desensitization approach for several hypersensitivities. True potential of ASIT for peanut allergy has yet to be achieved due to the concerns of efficacy, safety, cost, and convenience of prevailing investigational ASIT methods. Skin-targeted ASIT offers an attractive solution to treatment of peanut allergy since the skin is an easily accessible organ that contains high-density antigen-presenting cells (APCs) and immune-accessory cells.
Allergic skin rashes are commonly encountered; however, the etiology is often elusive. By analyzing retrospective allergy panels, we hope to identify unique patterns. The results from 777 patients (524 female, 253 male) were sorted by month, gender and age and then analyzed using the Chi-squared test. The most common allergen identified was D. farina and pteronyssinus, which accounted for one third of all positive tests. Females were more predisposed to be allergic to cow ’s milk (p = 0.0191), hazelnut (p = 0.0273), wheat (p = 0.0072), shrimp (p = 0.
Desmogleins (Dsgs) are cadherin family members present in desmosomes and essential for epidermal integrity. Dsgs associate with lipid raft membrane microdomains, but the physiological significance of this association is not clear. Here, we report that the Dsg transmembrane domain (TMD) is the primary determinant of lipid raft association. Further, we identify a novel mutation in the DSG1 TMD (G562R) that causes severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome. Cell based experiments revealed that the Dsg1 TMD mutant is defective in both lipid raft and desmosome association.
The epidermis is a multi-layered and regenerating epithelial tissue that renews itself by proliferation of basal keratinocytes and the basal-to-suprabasal transition of differentiating cells. A desmosomal cadherin called desmoglein-1 (Dsg1) promotes basal cell delamination to the suprabasal layer via actin remodeling, a process which requires proper positioning of Dsg1 on the plasma membrane. The importance of Dsg1 positioning in epidermal function is reflected by the existence of mutations and autoantibodies that disrupt Dsg1 plasma membrane localization such as Severe dermatitis, multiple Allergies, and Metabolic wasting...
An effective epidermal barrier requires intercellular junctions including desmosomes and gap junctions (GJ). While desmosomes play a role in cell-cell adhesion, GJs facilitate small molecule transfer across cell membranes. GJs are composed of connexins (Cx), with Cx43 (encoded by GJA1) most abundantly expressed in skin. Severe dermatitis, multiple Allergies and Metabolic wasting (SAM) syndrome is a condition caused by biallelic mutations in DSG1. SAM syndrome can manifest with skin lesions reminiscent of Erythrokeratodermia Variabilis, a group of disorders associated with mutations in Cx-encoding genes which result in Cx43 dysregulation.
Histamine-independent mechanisms mediate the itch associated with the majority of dermatologic and systemic diseases. SLIGRL is a prototypic histamine-independent pruritogen. It is derived from the tethered sequence of the PAR2 receptor. Previous studies have demonstrated that SLIGRL activates mouse MrgprC11 to induce itch. We demonstrate that SLIGRL specifically activates human MRGPRX2, a receptor implicated in itch, allergy, and inflammation. We also evaluated the effect of QWF, an MRGPRX2 antagonist, on SLIGRL-induced activation of Mrgprs and SLIGRL-induced itch in mice.