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Startup Turns to Liquified Silk for Tissue Regeneration

A Boston-area plastic surgery startup wants to use a reverse-engineered form of an ancient medical material in tissue regeneration for aesthetics and medical purposes. Sofregen is working on tissue regeneration using liquefied silk protein, which has emerged from academic research in recent decades. Liquefied silk protein offers biocompatibility and engineering controllability without using harsh chemicals, according to Sofregen chief medical officer Anh Hoang. Hear Anh Hoang discuss the use of silk protein in implantable devices on April 18, 2018, at BIOMEDevice Boston. Use promo code "MDDI" for 20% off conference registration and free expo access. “It’s already used in sutures and mesh,” Hoang said. “We can control how much protein content there is. We can control the mechanics of it.” Silk has been used in medical applications for about 2,000 years, but the first mass-produced, sterile silk sutures were invented by Johnson &Johnson in 1887. Working with technology developed at Tufts University and the University of Pittsburgh, Sofregen is developing a silk scaffold that can be injected to provide immediate bulking of tissue and eventually help it regenerate. It has applied for FDA approval. The first indication would be to bulk up vocal folds so they can come together to produce the sounds used for speech. After the initial bulking, the silk scaffold would be replaced by the patient’s own tissue over the course of 2...
Source: MDDI - Category: Medical Devices Authors: Tags: BIOMEDevice Boston Materials Source Type: news

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This study was aimed to evaluate whether ROS could modulate Th2-type inflammation in keratinocytes. Allergen and non-allergen was tested in modulating Th2-type inflammation. Materials: For experiments, normal human epidermal keratinocytes (NHEKs) were treated with an allergen (HDM) and non-allergen (compound 48/80, C48/80) under the same condition.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
The red meat allergy caused by tick bites are increasing worldwide. It is known that IgE epitope of major red meat allergens is galactose--1,3-galactose ( α-Gal). Thus, the patients with red meat allergy have a high risk to develop anaphylaxis to taking cetuximab that chimera-type monoclonal antineoplastic drug, because it also contains α-Gal, and its cross-reaction. The α-Gal specific IgE (sIgE) test by CAP-fluoro-enzyme immunoassay (FEIA) is one of the most sensitive examination to identify the patients with red meat allergy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
While atopic dermatitis (AD) is known to impact sleep among clinical populations, little is known about the association between AD disease activity and sleep over time among community-based populations. We aimed to determine whether children with active AD have impaired sleep duration and quality compared to children without AD throughout childhood using data from 11,432 individuals in the Avon Longitudinal Study of Parents and Children, a population-based prospective birth cohort in the UK. The annual period prevalence of active AD (assessed by maternal report of a typical itchy flexural rash in the past year, as defined ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
This cross-sectional, survey-based study assessed US physicians experiences and perceptions of the risks and benefits of non-biologic systemic therapies, prior to the introduction of biologics, for moderate-to-severe atopic dermatitis (AD). Physicians specializing in dermatology, allergy/immunology or primary care, who prescribed oral systemic immunosuppressants (IMMs) or steroids (SSs) for AD, and who had ≥10 office visits for AD in the year prior to selection were identified from the HealthCore Integrated Research Database (08/01/1511/04/16).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Background: There were increasing cosmetic adverse reaction in China, mostly cosmetic contact dermatitis (CCD), with the development of cosmetics industry. Objective: To identify the allergens of cosmetics which responsible for CCD in China. Methods: Totally 343 subjects, including 125 CCD patients from dermatological clinic and 218 cosmetics consumers with allergic history, were patch-tested with a cosmetic series (C-1000 series including 56 allergens, Chemotechnique Diagnostics).Allergens were applied to the upper back using IQ Chambers for 48 hours, and the results were recorded at Day 3 to Day 5 according to ICDRG standard scoring system.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Cosmetics are widely used in our daily life, and are known to be a common cause of skin allergy and irritation. Skin allergic and irritant reactions to cosmetics are routinely tested following a standard patch test protocol as a safety requirement in China. In order to learn the general prevalence of skin allergy and irritation to cosmetics and the associated factors, we have analyzed the data collected during 2011 and 2017 from a main testing center in Shanghai, China. The dataset includes 10178 individual visits (age 19-66), with an average number of 60 patch test case reactions per individual visit.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Background: A high prevalence of hypersensitivity to cetuximab has been reported in Southeast areas of the United States. IgE antibodies against cetuximab were present in the patients with cetuximab hypersensitivity and the antibodies were specific for galactose-alpha-1,3-galactose (alpha-Gal) in cetuximab heavy-chain. We have also determined that patients with red meat allergy have IgE antibodies against alpha-Gal in Japan. In 2013, 13 patients with SCC of the head and neck were treated with cetuximab in Matsue Red Cross Hospital, and four of the 13 patients (30.8%) had anaphylactic shock during first infusion of cetuximab.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Desmoglein 1 (Dsg1) is a desmosomal cadherin that first appears during skin development at the time of periderm formation, and later is expressed in basal cells as they begin to differentiate and transit into the suprabasal layers of stratified epidermis. Its importance in epidermal function is underscored by human diseases caused by aberrant Dsg1 expression, such as Striate Palmoplantar Keratoderma (SPPK) and SAM (Severe Skin Dermatitis, Allergies and Metabolic Wasting). In contrast to other mouse desmosomal cadherins, Dsg1 is present as three, tandem α, β and γ genes in the cadherin cluster, which has hi...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Growth Factors, Cell Adhesion and Matrix Biology Source Type: research
Desmogleins are trans-membranal proteins traditionally considered to play a critical role in the maintenance of cell-cell adhesion in the epidermis. Severe skin dermatitis, multiple allergies and metabolic wasting (SAM) syndrome is a rare and usually inherited condition caused by bi-allelic mutations in DSG1 encoding desmoglein 1. The disease was initially reported to manifest with life-threatening erythroderma, failure to thrive, atopic manifestations, recurrent infections, hypotrichosis and palmoplantar keratoderma.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
Recent studies suggest that the sensitization to food allergens commonly occur through the skin. We previously established a mouse model of epicutaneous sensitization using ovalbumin (OVA). BALB/c mice are sensitized by three-time application of OVA to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of OVA undertaken. Allergic symptoms such as fall of rectal temperature are observed after oral challenge (Yu R et al, Experimental Dermatology. 2017;26:778-784). In the present study, we examined whether oral administration of food is effective for the prevention and treatment of food allergy c...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
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