Polymer Brush-Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery.

Polymer Brush-Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery. Chemphyschem. 2018 Mar 24;: Authors: Zhang L, Bei HP, Piao Y, Wang Y, Yang M, Zhao X Abstract Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug delivery systems (DDSs) to transport a variety of drug/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes endows them with intelligent and controllable drug delivery properties, i.e., the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature variation, light irradiation, enzyme, ultrasound, or redox potential, thus maximizing their therapeutic efficiency and minimizing side effects. These polymer brushes can also increase the stability and extend the release period of the loaded cargoes. This review presents an overview of the recent research progress on stimuli-responsive controlled DDSs based on polymer brush-grafted MSNs. Utilizing the switching abilities of the grafted responsive polymer brushes, the smart DDSs show great potential in biomedical applications, especially in cancer therapy. PMID: 29575338 [PubMed - as supplied by publisher]
Source: Chemphyschem - Category: Chemistry Authors: Tags: Chemphyschem Source Type: research