Increased complement component 4 (C4) gene expression in the cingulate cortex of rats exposed to late gestation immune activation

The largest genetic study of schizophrenia confirmed the strong genetic association with the major histocompatibility complex (MHC) locus (Ripke et al., 2011). Whilst the link between schizophrenia and the MHC locus is not yet fully elucidated, there is significant interest in immune dysfunction as an underlying pathology in schizophrenia. Recently Sekar et al. (2016) presented strong evidence for a role of complement component 4 (C4) in schizophrenia by showing that some of the variation in the MHC locus in schizophrenia is linked to the C4 gene.

Source: Schizophrenia Research - March 26, 2018 Category: Psychiatry Authors: Ryan J. Duchatel, Crystal L. Meehan, Lauren R. Harms, Patricia T. Michie, Mark J. Bigland, Doug W. Smith, Phillip Jobling, Deborah M. Hodgson, Paul A. Tooney Tags: Letter to the editor Source Type: research