Lung transplant drug enters human testing in culmination of decades of work

(University of Virginia Health System) In the culmination of decades of research at the University of Virginia Health System, doctors have begun human testing of a drug they hope will one day save many lives among lung-transplant recipients.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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ConclusionsMucormycosis involved mainly the sinu ‐orbital site and affected children>10  years. Despite aggressive treatment with high‐dose L‐AmB and timely surgical debridement, the mortality rate remains still high.
Source: Mycoses - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research
Collaboration Combines CollPlant’s Proprietary rhCollagen-based BioInk Technology and United Therapeutics’ Regenerative Medicine and Organ Manufacturing Capabilities NESS ZIONA, Israel, November 12, 2018 -- (Healthcare Sales &Marketing Network) -- Col... Devices, Regenerative Medicine, Licensing CollPlant, United Therapeutics, Lung Biotechnology PBC, 3D bioprinting
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
ConclusionPatients who are at risk for SCA are patients who have had a cardiac arrest due to ventricular fibrillation (VF) or sustained ventricular tachycardia (SVT), those with familial or inherited condition with sudden cardiac arrest risk, myocardial infarction with an ejection fraction (EF) of less than or equal to 35%, dilated cardiomyopathy (including NICM), with an EF of less than or equal to 35%, ICD explanations, and other conditions with high risk of ventricular tachycardia (VT) or VF are candidates for the WCD.The sample of data was from 186 patients. However, more patients were likely candidates but may not hav...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
ConclusionA diagnosis of LC following LTx remains rare. LC in the explanted lung seems to have no impact on survival for early ‐stage disease. LC in the transplanted or native remaining lung after LTx has poor prognosis.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
ConclusionPirfenidone and nintedanib do not modulate expression of senescence markers, levels of p ‐SMAD3 or the amount of fibrosis in IPF lungs. Treated patients have less histopathological evidence of acute lung injury at the time of lung transplantation.
Source: Histopathology - Category: Pathology Authors: Tags: Original Article Source Type: research
This study aimed to evaluate preoperative nutritional assessment as a predictor of LTX outcomes.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
CONCLUSION:  In a post-LTx setting, LUS represents a clinical novelty as a feasible diagnostic and monitoring tool to identify pathological pulmonary complications in the early post-operative phase. PMID: 30414162 [PubMed - as supplied by publisher]
Source: Ultraschall in der Medizin - Category: Radiology Authors: Tags: Ultraschall Med Source Type: research
ConclusionPreoperative thoracic epidural placement provides improved analgesia without increased morbidity following lung transplantation.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
ConclusionPercutaneous lung nodule needle biopsy can be performed accurately using cone-beam CT with navigational overlay.
Source: Pediatric Radiology - Category: Radiology Source Type: research
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