Proton RT for Prostate Cancer Has Reduced Toxicity, Higher Cost vs Other RT Options

Proton radiation therapy offers some reduced toxicity over IMRT in patients under the age of 65 with prostate cancer, but its cost is nearly double.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Genitourinary Cancers News Prostate Cancer Source Type: news

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Little is known about the toxicity of additional pelvic lymph node irradiation in men receiving intensity-modulated radiotherapy (IMRT) for prostate cancer. The aim of this study was to compare patient-reported outcomes following IMRT to the prostate only (PO-IMRT) versus the prostate and pelvic lymph nodes (PPLN-IMRT).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The objective of this study was to validate the discriminatory power of these subregions with respect to the whole organs in a large independent population.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Scientific Letters Source Type: research
In this study, a phantom, containing a metal with high atomic number, was prepared for intensity-modulated radiotherapy (IMRT) treatment plans to be used in quality assurance (QA) procedures. Two sets of image files, one without metal artefact correction (ORG) and another with MAR correction (MAR+), were sent to the treatment planning system. In this study, 12 IMRT treatment plans with different fields and segment numbers were calculated. The normal tissue complication probability (NTCP) values of imaginary organs at risk (OARs), such as the rectum and bladder, were investigated, as was the difference in dose maps for ORG ...
Source: Radiation and Environmental Biophysics - Category: Physics Authors: Tags: Radiat Environ Biophys Source Type: research
Authors: Konat-Bąska K, Chicheł A, Staszek-Szewczyk U, Maciejczyk A, Matkowski R Abstract Purpose: Prostate and colorectal cancers are the first and the third most popular malignancies in male population, in which some patients may develop these tumors metachronously or synchronously. At present, there are no standard recommendations, and oncologists need to provide an optimal management for two different cancers with an acceptable risk of possible treatment of adverse effects. Material and methods: This case report presents the treatment of a 61-year-old patient suffering from synchronous prostate and rectal...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
The normal tissue objective (NTO) is a tool used in inverse-planned intensity-modulated radiation therapy to reduce dose spreading to the surrounding tissues. Only a few studies in the present literature are dedicated to understanding the influence of the NTO in radiation therapy planning in patients with prostate cancer or its consequences in the reduction of the dose in the surrounding healthy tissues.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Research Article Source Type: research
Dose-escalated external beam radiation therapy results in improved outcomes for patients with prostate cancer, but at the cost of increased gastrointestinal toxicity [1 –3]. Indeed, the prostate is not a static organ, and nearby critical structures present a limiting factor to delivering higher doses to the target volume. Methods including image-guided radiation therapy (IGRT) and intensity modulated radiation therapy (IMRT) have been developed to help reduce tox icity rates by improving confidence in target localization and by increasing dose conformity, respectively.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
MONDAY, March 23, 2020 -- For men with intermediate- and high-risk prostate adenocarcinoma, 10-year outcomes are similar with conventionally fractionated intensity-modulated radiation therapy (C-IMRT) or moderate hypofractionated IMRT (H-IMRT),...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
A web-based tool can help predict functional outcomes for five years after treatment of localized prostate cancer with radical prostatectomy (RP), intensity-modulated radiation therapy (RT), or active surveillance, researchers say.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
CONCLUSION: Combined RT + HT treatment was associated with temporary lower scores in sexual and hormonal HRQoL compared with RT only. Intermediate- and high-risk CaP patients should be counseled about the possible declines in HRQoL associated with HT. PMID: 32139288 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
CONCLUSION: H-IMRT failed to demonstrate superiority compared with C-IMRT in long-term disease outcomes. PMID: 32119599 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
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