Back in the game after stem cell transplant

By Irene Sege Some 100 days after receiving a stem cell transplant to cure his severe aplastic anemia, Behaylu Barry still couldn’t invite friends into his home. He wouldn’t be returning to school until January because his immune system needs the time to get strong enough to fight the pathogens present in indoor spaces. But 13-year-old Behaylu was doing so well that his doctor cleared him to play soccer – outdoors, of course — for the first time since February, when he was diagnosed with the life-threatening blood disorder shortly before he was to join the competitive soccer team that had just selected him. So Behaylu recently walked on the field with his old traveling team, the Exeter (NH) Hawks, for a two-game pre-season tournament. The Hawks won, 4-1 and 6-1, with Behaylu, playing center midfield, scoring two assists in the first game, three in the second – and a goal in the second game with a head shot from the corner. His mother, Midori Kobayashi, cheered so much and so loudly that she lost her voice. “Soccer is always pretty awesome,” Behaylu says. “This is the biggest step back to a normal life. One of them was swimming. One was hanging out with friends. Playing soccer is two steps. It’s one giant leap.” “I know he pushed himself beyond his limits,” says his father, Aidan Barry. “But he’s 13. What do you do? Put him in a cage? It was a magical time for everyone.” As rare as severe...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: All posts Aplastic anemia Dana-Farber/Boston Children's Transplant center Stem cell Stem Cell Transplant Program Source Type: news

Related Links:

Authors: Cui T, Li Z, Zhou Q, Li W Abstract Diploidy is the typical genomic mode in all mammals. Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells, which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale. To date, a multitude of haploid stem cell types from mouse, rat, monkey and humans have been derived, as more are in development. They have been applied in high-throughput genetic screens and mammalian assisted reproduction. Here, we review t...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
(American Association for Cancer Research) A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Wiley) A new study reveals that many people with cancer use marijuana, and rates of use in the US have increased over time. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study also found that patients with cancer are more likely to use prescription opioids than adults without cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Jared A Sewell ; Jeff A LongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaGene regulation in both plants and animals is orchestrated by complex interactions between multiple, often times related, factors. How these related factors interact and compete to alter gene expression is a key question that is not fully understood. In Arabidopsis, the Class III Homedomain-Leucine Zipper (HD-ZIPIII) family of transcription factors regulates key developmental processes such as shoot stem cell formation and display complex genetic interactions. We show that ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
Contributors : Yu-Chan Chang ; Michael HsiaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe demonstrate that RAB3C up-regulation significantly promoted cell migration and invasion in lower invasive colon cancer cell lines in vitro, as well as in distal metastases in vivoWe used microarrays to analyze the RAB3C regulated gene expression underlying invasion-metastasis cascade.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Jared A Sewell ; Jeff A LongSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaGene regulation in both plants and animals is orchestrated by complex interactions between multiple, often times related, factors. How these related factors interact and compete to alter gene expression is a key question that is not fully understood. In Arabidopsis, the Class III Homedomain-Leucine Zipper (HD-ZIPIII) family of transcription factors regulates key developmental processes such as shoot stem cell formation and display complex genetic interactions. We show that HD-ZIPIIIs for...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
Contributors : K S Rakesh ; Dawood B Dudekula ; Ramaiah Nagaraja ; Minoru S Ko ; Yulan Piao ; David Schlessinger ; Ramamoorthy Kalidoss ; Ravi SirdeshmukhSeries Type : Expression profiling by arrayOrganism : Mus musculusWe have studied protein expression in mouse embryonic stem (mES) cells- R1-9 and identified the largest complement of proteins reported thus far for mES cells, using on-line LC-MS/MS analysis. With support from a transcriptome profile of the same mES cell line, we arrived at an integrated dataset of 9,370 protein expressions that may be useful to understand the stem cell dynamics. 6,278 protein identificati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 21 April 2019Source: Journal of Molecular StructureAuthor(s): Rafael G. Silveira, Beatriz N. Cunha, Juan C. Tenório, Deborah Victória Alves de Aguiar, Patricia da Cruz Souza, Boniek Gontijo Vaz, Javier Ellena, Alzir A. Batista, Felipe Terra MartinsAbstractAbiraterone acetate is a first choice prodrug to treat prostate cancer. New higher-solubility multicomponent crystal forms of the active compound abiraterone could substitute for the commonly used acetate prodrug. Here we prepare abiraterone hydrochloride monohydrate, which is the first multicomponent crystal form of this s...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in melanoma cells. Knockdown of Ku80 significantly suppressed melanoma cell proliferation and induced apoptosis, as well as enhanced the antitumor effect of melatonin in melanoma in vitro and in vivo. Overexpression of Ku80, however, promoted melanoma growth and increased the insensitivity of melanoma cells to melatonin. Mechanistically, we found that Ku80 bound to the PDK1 promoter and activated the transcription of PDK1. Moreover, we showed that the binding of Ku80 at the PDK-1 promoter was HIF1-&al...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: 1 August 2019Source: Carbohydrate Polymers, Volume 217Author(s): Yalda Rahbar Saadat, Ahmad Yari Khosroushahi, Bahram Pourghassem GargariAbstractSeveral scientific evidences have revealed probiotics implications on human health. A wide range of lactic acid bacteria (LAB) have been extensively studied for their ability to produce extracellular polysaccharides (EPSs), which are repeating units of mono/oligosaccharides with various chemical compositions and properties. Despite the conventional belief regarding probiotics that states bacteria must be alive to exert their beneficial effects, mounting evidence ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
More News: African Health | Anemia | Aplastic Anemia | Bleeding | Blogging | Cancer | Cancer & Oncology | Chemotherapy | Children | Education | Hospitals | Kidney Transplant | Kidney Transplantation | Learning | Lettuce | Liver | Liver Transplant | Lung Transplant | Pediatrics | Stem Cell Therapy | Stem Cells | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology