Assessment of Protein Prenylation Pathway in Multiple Sclerosis Patients

AbstractMultiple sclerosis (MS) is a chronic inflammatory disorder with several genetic and environmental factors being implicated in its pathogenesis. Protein prenylation as one of the important posttranslational modifications of proteins has crucial role in immune system regulation. In the current case –control study, we compared expression of five genes coding for the different subunits of proteins implicated in protein prenylation in 50 Iranian MS patients with those of healthy subjects. No significant difference has been found inFNTA andPGGT1B expressions between cases and controls. Spearman correlation analysis betweenFNTA relative expression and disease duration showed significant correlation in male patients (r = − 0.671,P = 0.024) but not female patients (r = 0.253,P = 0.12).FNTB expression was significantly higher in MS patients compared with healthy subjects. Spearman correlation analysis betweenFNTB relative expression and disease duration showed significant correlation in male patients (r = −0.876,P = 0.004) but not female patients (r = 0.296,P = 0.06).RABGGTA was significantly upregulated in total MS patients, total male patients, female patients aged between 30 and 40 and male patients aged>40 compared with corresponding control groups.RABGGTB was significantly downregulated in total MS patients, total female patients, and female patients aged>  40 compared with corresponding control groups. Totally, we demonstrat...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research