Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents.

CONCLUSION: Five derivatives were found to be active. Compound 5 was found to be the most potent inhibitor of ROS and NO compared to parent diclofenac 1 and standard drugs ibuprofen and L-NMMA, respectively. The most active compounds 1, 4, 5, 11 and 20 were found to be non-toxic on NIH-3T3 cells. Compound 4, 5, and 20 also showed good antiinflammatory potential, compound 11 and 16 showed moderate and low level of inhibition, respectively.
PMID: 29564980 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - March 21, 2018 Category: Chemistry Authors: Shah S, Arshia, Kazmi NS, Jabeen A, Faheem A, Dastagir N, Ahmed T, Khan KM, Ahmed S, Raza A, Perveen S Tags: Med Chem Source Type: research