Recent approval of xerese in Canada: 5% acyclovir and 1% hydrocortisone topical cream in the treatment of herpes labialis.

Recent approval of xerese in Canada: 5% acyclovir and 1% hydrocortisone topical cream in the treatment of herpes labialis. Skin Therapy Lett. 2014 Jun;19(3):5-8 Authors: Nguyen HP, Stiegel KR, Downing C, Stiegel KR Abstract Herpes labialis is a frequently occurring viral infection of the lips and oral mucosa. Recurring lesions are induced by viral reactivation and replication, but the symptoms leading to morbidity, such as pain and inflammation, are immune-mediated. The introduction of 5% acyclovir/1% hydrocortisone in a topical cream (Xerese™) represents a therapeutic strategy directed at both of these pathogenic processes. Applied at the onset of prodromal symptoms, this combination treatment has a good safety profile and is more effective in reducing healing time than antiviral or anti-inflammatory agents alone. Although it was US FDA-approved for herpes labialis in 2009, Xerese™ has only recently been approved for use in Canada in October 2013. Herein, we review the basic science and clinical studies that support the efficacy of this topical combination acyclovir-hydrocortisone product in treating herpes labialis and examine its safety profile, as well as touch upon other therapies that have been shown to be effective in treating this common viral condition. PMID: 25188362 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Abstract Herpetic neuralgia is a painful condition following herpes zoster disease, which results from Varicella-zoster virus reactivation in the dorsal or trigeminal sensory ganglia. Nevertheless, the pathophysiological mechanisms involved in herpetic neuralgia are not well understood. Recently, we identified, that neuroimmune-glia interactions in the sensory ganglion is a critical mechanism for the development of herpetic neuralgia. Here, we investigate the contribution of S100A9, a well-known pro-inflammatory molecule produced by myeloid cells, for the development of herpetic neuralgia using a murine model of H...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Herpes zoster is a viral skin disease caused by reactivation of latent varicella-zoster virus (VZV) in sensory ganglia [1]. Its characteristic symptom is a unilateral dermatomal vesicular rash, usually accompanied by acute herpetic pain (AHP) [2,3]. In some patients, the pain does not resolve when the vesicular rash heals, but continues for weeks and sometimes months or years; this chronic pain is termed “postherpetic neuralgia (PHN),” a debilitating condition that can be very difficult to manage, especially in the elderly in whom herpes zoster tends to be more severe [4,5].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Conclusion: This study will determine whether acupuncture is an effective and safe intervention for RHS. PROSPERO registration number: CRD 42019118283.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Background: Lesions of herpes labialis are caused by the herpes simplex virus type 1 and cause pain and aesthetic compromise. It is characterized by the formation of small vesicles that coalesce and rupture forming extremely painful ulcers, that evolve to crusts, dry desquamations until their complete remission. Currently the treatment of these lesions is done with acyclovir. Although it diminishes the symptomatology, it causes viral resistance and does not prevent the recurrence of the lesions. It is known that antimicrobial photodynamic therapy (aPDT) has numerous advantages, among them: the reduction of the time of re...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
AbstractPurpose of ReviewTranscutaneous electrical nerve stimulation (TENS) is widely used as a non-pharmacological approach for pain relief in a variety of clinical conditions. This manuscript aimed to review the basic mechanisms and clinical applications regarding the use of TENS for alleviating the peripheral (PNP) and central neuropathic pain (CNP).Recent FindingsBasic studies on animal models showed that TENS could alleviate pain by modulating neurotransmitters and receptors in the stimulation site and its upper levels, including the spinal cord, brainstem, and brain. Besides, many clinical studies have investigated t...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
AbstractAerophagia is a functional gastrointestinal disorder characterized by excessive swallowing of air associated with abdominal distension and pain, flatulence, belching, nausea, and vomiting. The purpose of the current study was to evaluate the effectiveness of an antecedent-based behavioral intervention on aerophagia with an adolescent female diagnosed with Lennox-Gastaut syndrome (LGS), severe intellectual disability, and herpes simplex virus infection of the central nervous system with chronic static encephalopathy. Results from a functional analysis and multiple-component aerophagia assessment suggested that aerop...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
Continuous epidural infusions are commonly used in clinical settings to reduce the likelihood of transition to postherpetic neuralgia via pain control. The purpose of this study was to compare the efficacy of ...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Research article Source Type: research
CONCLUSIONS: HSV may induce perianal infections, anal infections and HSV proctitis. Diagnosis of HSV1 and HSV2 using PCR is recommended. Anal and genital HSV infections are a risk factor for subsequent HIV infection. The risk is higher for HSV2 infection due to more frequent recurrences. PMID: 31965208 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Our objective was to develop comprehensive national estimates of the total burden of herpes zoster (HZ) among U.S. adults, including direct (ie, medical costs) and indirect (ie, productivity losses) costs, as well as its psychosocial impact (ie, quality of life losses). Using a patient-level microsimulation model, we projected health and economic outcomes among U.S. adults aged 18 years and older using a 10-year time horizon. We conducted a comprehensive systematic literature review to generate parameter values and conducted simulation modeling to generate our outcomes, including numbers of cases of uncomplicated HZ, posth...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
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