High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase
In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 Å resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism.
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Zhou, K. Fan, X. Li, Y. Zhang, C. Jin, T. Tags: glyceraldehyde-3-phosphate dehydrogenase asymmetric tetramer NAD phosphate-binding sites Streptococcus agalactiae group B streptococcus research communications Source Type: research