Brain's tiniest blood vessels trigger spinal motor neurons to develop

(Cedars-Sinai Medical Center) A new study has revealed that the human brain's tiniest blood vessels can activate genes known to trigger spinal motor neurons, prompting the neurons to grow during early development. The findings could provide insights into how amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders may develop. To make the discovery, investigators successfully re-created living tissues of the blood vessels and the spinal motor neurons -- which control muscles -- outside the body to show how they interact.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

Related Links:

Conclusion: We have investigated 217 differential pathways and 21 significant differential pathways between SALS and normal controls based on network strategy. The findings might provide potential biomarkers for detection and therapy of SALS clinically and give great insights to reveal molecular mechanism underlying this disease. However, how these pathways cooperated with each other is still not clear, and future study should focus on this aspect.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Authors: Torres-Navarro I PMID: 30502297 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Diagnostic criteria for amyotrophic lateral sclerosis (ALS) have been developed to standardise diagnosis and patient recruitment in trials. A research group of the World Federation of Neurology (WFN) devised the “El Escorial criteria” (EEC) (Brooks et al., 1994), which were later modified to increase their diagnostic sensitivity as the “revised El Escorial Criteria” (rEEC) (Brooks et al., 2000) with the objective of encouraging earlier inclusion in trials (Ross et al., 1998). The rEEC have been foun d to have high specificity, but to lack sensitivity, thus failing to promote earlier patient inclusio...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
CONCLUSIONS We identified a novel frameshift mutation associated with JALS. JALS and generally typical ALS, with the same FUS mutation, can appear in a family and present a phenomenon of anticipation. For diagnosis of central nervous system degeneration in adolescents with bulbar symptoms, great attention should be paid to JALS. PMID: 30507891 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Marta Simone, Antonio Trabacca, Elena Panzeri, Luciana Losito, Andrea Citterio, Maria Teresa Bassi
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: 50-Hz MF affects iron homeostasis in the in vitro SOD1G93A ALS model. PMID: 30513241 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Condition:   Amyotrophic Lateral Sclerosis Interventions:   Biological: Fecal microbiota transplantation;   Biological: Placebo Sponsors:   Azienda Ospedaliero-Universitaria di Modena;   University of Modena and Reggio Emilia;   Catholic University of the Sacred Heart;   Campus Bio-Medico University;   Azienda Ospedaliero-Universitaria Careggi;   Azienda Ospedaliera di Perugia;   University of Chieti;   University of Flor...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Letter Source Type: research
More News: ALS | Brain | Genetics | International Medicine & Public Health | Neurology | Study