Brain's tiniest blood vessels trigger spinal motor neurons to develop

(Cedars-Sinai Medical Center) A new study has revealed that the human brain's tiniest blood vessels can activate genes known to trigger spinal motor neurons, prompting the neurons to grow during early development. The findings could provide insights into how amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders may develop. To make the discovery, investigators successfully re-created living tissues of the blood vessels and the spinal motor neurons -- which control muscles -- outside the body to show how they interact.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Condition:   Amyotrophic Lateral Sclerosis Intervention:   Drug: Riluzole Oral Soluble film (ROSF) 50 mg Sponsors:   Aquestive Therapeutics;   inVentiv Health Clinical;   Covance Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
Brain and Behavior, EarlyView.
Source: Brain and Behavior - Category: Neurology Authors: Source Type: research
In this study, we aimed to compare the immunomodulatory properties of MSCs isolated from the bone marrow of patients suffering from ALS and healthy donors. Moreover, the influence of proinflammatory cytokines on the immunoregulatory functions of MSCs was also evaluated. We found that MSCs from ALS patients and healthy donors comparably affected mitogen-stimulated peripheral blood mononuclear cells and reduced the percentage of T helper (Th)1, Th17 and CD8+CD25+ lymphocytes. These MSCs also equally increased the percentage of Th2 and CD4+FOXP3+ T lymphocytes. On the other hand, MSCs from ALS patients decreased more strongly...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research
AbstractNeuromuscular disorder is a muscular and nervous disorder resulting in muscular weakness and progressively damages nervous control, such as amyotrophic lateral sclerosis (ALS) and myopathy (MYO). Its diagnosis can be possible by classification of ALS, MYO, and normal electromyogram (EMG) signals. In this paper, an effective method based on variational mode decomposition (VMD) is proposed for identification of neuromuscular disorder of EMG signals. VMD is an adaptive signal decomposition which decomposes EMG signals nonrecursively into band-limited functions or modes. These modes are used for extraction of spectral ...
Source: Health Information Science and Systems - Category: Information Technology Source Type: research
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Miguel Leal Rato, Gonçalo S Duarte, Tiago Mestre, Mamede de Carvalho, Joaquim J Ferreira
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 September 2018Source: Pharmacological ResearchAuthor(s): Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong ZhouAbstractIn amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93 A/cpYFP) tha...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
International Journal of Clinical Practice, EarlyView.
Source: International Journal of Clinical Practice - Category: Internal Medicine Authors: Source Type: research
Conclusions Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression.
Source: Journal of Speech, Language, and Hearing Research - Category: Speech-Language Pathology Source Type: research
Muscle&Nerve,Volume 0, Issue ja, -Not available-.
Source: Muscle and Nerve - Category: Internal Medicine Authors: Source Type: research
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