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Avita touts ReCell use in treating flesh eating bacteria, announces Chinese trial

Avita Medical (ASX:AVH) this week announced that its ReCell technology had been used to treat a patient with necrotizing fasciitis, and that it launched a Chinese trial of the device exploring its use treating second-degree burns. The ReCell autologous cell harvesting device is designed to use the patient’s own skin cells to treat a variety of skin issues, including burns, reconstructive and cosmetic procedures, the company said. The company said that a woman at Arizona’s Maricopa Integrated Health Systems Burn Center with necrotizing fasciitis, or flesh-eating bacteria, has been treated with its ReCell device. Avita Medical said that the patient, Peoria, Ariz. resident Christin Lipinski, and her treating physician Dr. Kevin Foster appeared today in a local news conference to discuss use of the device for treating the bacteria. The woman was treated with the ReCell device under an FDA approved compassionate use investigational device exemption program, according to a press release. Earlier this week, the company announced it launched a randomized, controlled trial of its ReCell device in China exploring the device’s usefulness in treating second degree burns. In the trial, which is being funded by the China National Health and Family Planning Commission, burn patients will be randomly selected to either receive treatment with the ReCell device, a standard-of-care treatment or one of two other treatments. The study is being led by Dr. Dahai Hu of The Fir...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Clinical Trials Wound Care avitamedical Source Type: news

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SCORTEN, used to predict prognosis in Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS/TEN overlap, is composed of clinical and laboratory variables during the first 24 hours of admission. Despite appropriate treatment, mortality in TEN remains high. Serum lactate on admission and following resuscitation, a powerful predictor of mortality in patients with thermal burns and sepsis, is not included in SCORTEN. Serum lactate is used to guide treatment in patients with severe burns.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Nowadays there are several diseases leading to partial or total atrophy of the hands, such as Epidermolysis Bullosa (EB), arthritis, osteoarthritis, burns or hand amputations. Patients from these diseases are affected to perform their daily activities which include eating, writing, brushing his teeth or drawing. Overall, these patients have their autonomy highly compromised. Current solutions for people with atrophied hands are very basic, mainly because the avalible options are prosthesis for people who lack a whole hand from the wrist up.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Patients who suffer thermal burn injuries while intoxicated with ethanol (approximately half of all severe injuries) experience more complications, longer hospital stays, and almost twice the mortality than non-intoxicated burn patients. Murine models of intoxicated thermal burn injury have revealed that the injury manifests with an acute pro-inflammatory response and delayed immunosuppression but the mechanisms driving these effects are still unclear. The lipid mediator Platelet-activating factor (PAF) promotes inflammation and immunosuppression in response to skin injury but it has not been characterized in intoxicated thermal burn.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
Skin pigmentation is a tightly regulated process that can be modulated via internal and external stimuli. Extrinsically, the skin often is exposed to environmental stimuli and stresses such as solar UV and infrared light, as well as to environmental pollution, all of which are able to modulate skin pigmentation. Post-inflammatory hyperpigmentation (PIH) is a common, acquired pigmentary disorder caused by inflammatory dermatoses (including acne-related hyperpigmentation), infections, reaction to drugs, dermatologic procedures, and external injury (burns, frictions, trauma).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
There is not enough evidence available to guide wound care management in patients with Stevens-Johnson Syndrome (SJS)/ Toxic Epidermal Necrolysis (TEN). Current guidelines are based on expert opinion and mimic burn wound treatments, including the use of silver-impregnated dressings. Silver-containing dressings reduce the risk of invasive infection by minimizing the bacterial colonization of wounds. Evidence from small clinical trials in burn patients and a retrospective study in SJS/TEN patients indicate that they offer the advantage of not requiring daily dressing changes, which may damage the healing epidermis, and minim...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology and Drug Development Source Type: research
Cysteinyl leukotrienes (CysLTs; LTC4, LTD4, and LTE4) are inflammatory mediators known for their involvement in bronchoconstriction, asthma and allergy, and primarily signal through the receptors CysLT1 and CysLT2. Interestingly, recent studies have found that CysLT receptors are expressed in normal skin, and that CysLT signaling may interfere with wound healing. Furthermore, our preliminary data show that enzymes associated with CysLT synthesis are highly upregulated in burned murine skin compared to healthy skin, while a previous study showed that blister fluids from burn patients contain high LTC4 levels.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
In this study we used a porcine burn wound model to explore the expression and functions of laminins and some important dermal matrix proteins and regulators in wound repair. Swine were used for our animal model since their skin is morphologically similar to human skin.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
This study analyses the epidemiological characteristics of bus fires in mainland China over the past 10 years to develop prevention strategies and emergency procedures for such incidence and the resulting casualties. METHODS: We collecte...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Follow me on Twitter @RobShmerling Let’s say you’ve started working out at the gym and you’re wondering what you can do for your aching muscles. How does this sound? Put on a pair of gloves, shoes, socks, and a protective headband to cover your ears and face — but wear little else. Then step into a cold room for three to four minutes. By “cold” I mean really cold: between −100° C and −140° C (which is −148° F to −220° F)! If that sounds good to you (really?), you may already be using whole body cryotherapy (WBC). And if it sounds terrible to you (o...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Health Source Type: blogs
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