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Obesity surgery prevents severe chronic kidney disease and kidney failure

(University of Gothenburg) Patients that underwent weight-loss surgery ran a significantly lower risk of developing severe chronic kidney disease and kidney failure, when compared to conventionally treated patients, according to a study published in International Journal of Obesity.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correction of these factors in native kidneys slows progression of chronic kidney disease. The aim of this study was to analyze the association between control of non-immunological factors and annual decline of GFR.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Publication date: Available online 13 April 2018 Source:American Journal of Kidney Diseases Author(s): Nisa Desai, Claudia M. Lora, James P. Lash, Ana C. Ricardo Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among His...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
AbstractBackgroundChronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that abdominal obesity is a risk factor for cardiovascular mortality. We investigated the link between sagittal abdominal diameter (SAD) and Framingham risk score in non-dialysis CKD patients.MethodsIn a cross-sectional study, we enrolled 307 prevalent non-dialysis CKD patients (175 males, aged 50.7  ± 17.04 years). SAD and Framingham risk score were measured.ResultsFramingham cardiovascular disease risk score was independently predicted by SAD (P 
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ABSTRACTBackgroundNormal-weight obesity (NWO), defined by a normal body mass index (BMI) and high body fat percentage, has been shown to be associated with cardiometabolic dysfunction and an increased risk of cardiovascular disease and mortality in the general population. However, little is known about the clinical implications of NWO among patients with chronic kidney disease (CKD).ObjectiveThe aim of this study was to assess the characteristics and outcomes of nondiabetic CKD patients with NWO.DesignA total of 178 nondiabetic patients with stages 3 –5 CKD were prospectively followed for a median of 4.9 y. The patie...
Source: American Journal of Clinical Nutrition - Category: Nutrition Source Type: research
Conclusions:This study demonstrates an association between glomerular hyperfltration and obesity ‑related hypertension in a large sample of the Iranian pediatric population, independently of other classical risk factors.Keywords:Cardiometabolic risk factors, children and adolescents, estimated glomerular fltration rate
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Abstract Obesity and increased lipid availability have been implicated in the development and progression of chronic kidney disease. One of the major sites of renal lipid accumulation is in the proximal tubule cells of the kidney, suggesting that these cells may be susceptible to lipotoxicity. We previously demonstrated that loss of hepatic BVRA causes fat accumulation in livers of mice on a high-fat diet. To determine the role of BVRA in mouse proximal tubule cells, we generated a CRISPR targeting BVRA for a knock-out in mouse MCT proximal tubule cells (BVRA KO). The BVRA-KO cells had significantly less metabolic...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
This study suggests that chronic administration of captopril, but not furosemide, could be beneficial in patients with HFpEF, particularly in those with comorbidities such as obesity, diabetes, and dyslipidemias.
Source: Journal of Cardiovascular Pharmacology - Category: Cardiology Tags: Original Article Source Type: research
Abstract Background: Normal-weight obesity (NWO), defined by a normal body mass index (BMI) and high body fat percentage, has been shown to be associated with cardiometabolic dysfunction and an increased risk of cardiovascular disease and mortality in the general population. However, little is known about the clinical implications of NWO among patients with chronic kidney disease (CKD). Objective: The aim of this study was to assess the characteristics and outcomes of nondiabetic CKD patients with NWO. Design: A total of 178 nondiabetic patients with stages 3-5 CKD were prospectively followed for a media...
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
Abstract Vancomycin, discovered in 1953 and widely used today, has a nephrotoxic potential that has long been debated. The frequency of renal involvement is variable and can range from 5% to 30% depending concomitant risk factors: overdose, chronic kidney disease, obesity, hypovolemia, and use of other nephrotoxic drugs as aminoglycosides. Its association with piperacillin-tazobactam also appears to increase the risk of nephrotoxicity. This hypothesis should be confirmed experimentally. Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms ex...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Conclusions (1) a standard 240  mg dose results in gentamicin Cmax values below 15  mg/L in the majority of the patients, (2) eGFR formulas to estimate kidney function will have to be evaluated for their usefulness in the Namibian patient population.
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
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