New study demonstrates no benefit to off-label hand osteoarthritis therapy

A drug that is sometimes used as an off-label treatment forosteoarthritis of the hand may not actually provide the presumed benefits, according to new research. Arthritis Research UK has funded a study from the University of Leeds that calls into question the current practice of offering the drughydroxychloroquine off-label as a means ofpain relief when conventional medication has failed, as the evidence suggests it is likely to be ineffective. No benefit from off-label therapy Currently, the common first-line treatment for hand osteoarthritis is paracetamol, non-steroidal anti-inflammatorydrugs or opioids, but doctors often use hydroxychloroquine as a backup option for patients who experience adverse reactions to initial therapies. This is despite the fact that hydroxychloroquine is not specifically licensed for this condition, and that no comprehensive research has been done into whether it is actually effective in these cases. As such, this new study aimed to analyse the drug's performance among 248 patients attending 13 NHS hospitals in England. Data published in the Annals of Internal Medicine showed that patients initially reported a small reduction in the severity of pain when receiving hydroxychloroquine, but this improvement soon plateaued, with any benefits being no more pronounced than when a placebo was used. Measurements of grip strength and structural damage delivered similar results. Do current medical practices need to change? Hydroxychloroquine is known t...
Source: Arthritis Research UK - Category: Rheumatology Source Type: news

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Conclusion: The present study suggests that the extract of LMZ attenuates CFA-induced inflammatory pain by suppressing the ERK1/2 and NF-κB signaling pathway at both peripheral and central level. Introduction Pain is one of the most common symptoms in clinical practice, and inflammatory pain is the most important type of pain (Patapoutian et al., 2009). Inflammatory pain is a growing global health problem. In generally, there is a common course of progression in inflammation and pain share. When patients experience inflammation, they may develop hyperalgesia or allodynia to various mechanical, thermal, or che...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study had a large sample size and obtained positive findings in both patients’ subjective ratings and in inflammatory marker levels. It demonstrates the benefits of adding Tai Chi to an antidepressant regimen but does not examine the specific effect of Tai Chi on depression.Field et al. (16) investigated the effects of combined Tai Chi/yoga in 92 prenatally depressed pregnant women. They found that women practicing Tai Chi/yoga (20 min per week for 12 weeks) had lower depression, anxiety, and sleep disturbance scores compared to a waitlist control group (Table 1). This study had a large sample size and provided ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: Despite lack of evidence for use of medical cannabis in rheumatology patients, we acknowledge the need to provide empathetic and pragmatic guidance for patient care. This position statement aims to facilitate the dialogue between patients and healthcare professionals in a mutually respectful manner to ensure harm reduction for patients and society. PMID: 30647183 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
You're reading Natural Remedies That Help Relieve Your Joint Pain, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading What Are The Best Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. Accor...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
Alex Bekker, Carolyn Kloepping, Shemille CollingwoodJournal of Anaesthesiology Clinical Pharmacology 2018 34(4):450-457 Oral formulations of meloxicam, a preferential cyclooxygenase-2 (COX-2) inhibitor, have long been used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, as well as various pain syndromes of skeletomuscular origin (e.g., low back pain). However, these preparations are rarely indicated for the treatment of acute pain due to a poor dissolution rate and consequently a slow onset of action. The recent introduction of an intravenous (IV) NanoCrystal Colloidal Dispersion formulation opens u...
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
ConclusionsMusculoskeletal pains are common among garment workers of Bangladesh and may cause morbidity, disability, and work loss. Our findings may be important to plan ergonomic measures preventing complaints and may be of interest for international companies ordering garments in Bangladesh.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Ankylosing spondylitis (AS) is an extreme form of inflammatory arthritis which always leads to bony fusion of vertebral and chronic pain of back. A lot of genes including interleukin, matrix metalloproteinases (MMPs), and endoplasmic reticulum aminopeptidase were found associated with AS. MMP family members were involved in the autoimmune disease and orthopedic diseases such as rheumatoid arthritis and osteoarthritis, while few studies concentrated on the correlation between single-nucleotide polymorphisms (SNPs) in MMP and AS. In addition, there is no report on the relationship between MMP-8 and AS. To investigate the ass...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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