Machine learning may identify medulloblastoma subtypes

The combination of machine learning and radiomics can predict the molecular...Read more on AuntMinnie.comRelated Reading: Is artificial intelligence ethical in healthcare? Deep learning may produce sharp reductions in DBT dose Deep learning can detect intracranial calcifications on CT Deep learning can quantify CAC on low-dose CT Deep-learning algorithm can stratify lung nodule risk
Source: Headlines - Category: Radiology Source Type: news

Related Links:

Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Investigators at the NCI Laboratory of Immune Cell Biology  discovered an Anti-TNF Induced Apoptosis (ATIA) protein, which protects cells against apoptosis.  ATIA is highly expressed in glioblastoma and astrocytomas and its inhibition results in increased cell sensitivity to TNF-related apoptosis-inducing ligand induced cell death.  Hence, ATIA assays ma y enable clinicians to effectively stratify patients for appropriate treatment.  ATIA exists in a soluble form that can be detected in culture medium of ATIA expressing cells indicating it could be used to develop a non-invasive, blood based diagnostic ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Publication date: 10 July 2018Source: Cell Reports, Volume 24, Issue 2Author(s): Seçkin Akgül, Yinghua Li, Siyuan Zheng, Marcel Kool, Daniel M. Treisman, Chaoyang Li, Yuan Wang, Susanne Gröbner, Tsuneo Ikenoue, Yiping Shen, Sandra Camelo-Piragua, Gerald Tomasek, Sebastian Stark, Vinay Guduguntla, James F. Gusella, Kun-Liang Guan, Stefan M. Pfister, Roel G.W. Verhaak, Yuan ZhuSummaryMost human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a ...
Source: Cell Reports - Category: Cytology Source Type: research
Conditions:   Neuroendocrine Tumors;   Insulinoma;   Gastrinoma;   Glucagonoma;   Vipoma;   Pheochromocytoma;   Paraganglioma;   Neuroblastoma;   Ganglioneuroma;   Medullary Carcinoma;   Pituitary Adenoma;   Medulloblastoma;   Merkel Cell Carcinoma;   Small-cell Lung Cancer;   Meningioma;   Carcinoid Interventions:   Diagnostic Test: 68Ga-DOTATOC PET/CT;   Diagnostic Test: 18F-FDG PET/CT Sponsor:   British Columbia Cancer Agency Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Brain tumors are the most common solid tumor among children under 15, representing 20% of childhood cancers. Prognosis and therapeutic options vary dramatically based on histologic and molecular profiles. We have studied 222 brain tumors using the CHOP Comprehensive Solid Tumor Panel, which interrogates 238 cancer genes and 110 fusion partners. The most common tumors are pilocytic/pilomyxoid astrocytoma (67), medulloblastoma (23) and diffuse midline glioma (17). Clinically significant genomic alterations were identified in 93% of patients.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionOptimum diagnosis for non-traumatic intra-medullary spinal cord lesions can be achieved by using DWI and ADC value measurement.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Publication date: 11 June 2018Source: Cancer Cell, Volume 33, Issue 6Author(s): Dan Zhu, Satoru Osuka, Zhaobin Zhang, Zachery R. Reichert, Liquan Yang, Yonehiro Kanemura, Ying Jiang, Shuo You, Hanwen Zhang, Narra S. Devi, Debanjan Bhattacharya, Shingo Takano, G. Yancey Gillespie, Tobey Macdonald, Chalet Tan, Ryo Nishikawa, William G. Nelson, Jeffrey J. Olson, Erwin G. Van MeirSummaryAdhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: 26 June 2018Source: Cell Reports, Volume 23, Issue 13Author(s): Karthiga Santhana Kumar, Anuja Neve, Ana S. Guerreiro Stucklin, Claudia M. Kuzan-Fischer, Elisabeth J. Rushing, Michael D. Taylor, Dimitra Tripolitsioti, Lena Behrmann, Daniel Kirschenbaum, Michael A. Grotzer, Martin BaumgartnerSummaryThe microenvironment shapes cell behavior and determines metastatic outcomes of tumors. We addressed how microenvironmental cues control tumor cell invasion in pediatric medulloblastoma (MB). We show that bFGF promotes MB tumor cell invasion through FGF receptor (FGFR) in vitro and that blockade of FGFR rep...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: August 2018Source: Journal of Clinical Neuroscience, Volume 54Author(s): Hirotomo Tanaka, Daisuke Yamamoto, Mitsuru Ikeda, Masashi Morikawa, Kayo Ueda, Kazuhiro Tanaka, Takashi Sasayama, Eiji KohmuraAbstractThe 2007 World Health Organization Classification of Tumors of the Central Nervous System (CNS) categorized embryonal tumors of the CNS into three classes: medulloblastoma, CNS primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor. Due to the lack of specific histological features, it was sometimes difficult to accurately differentiate CNS embryonal tumors pathologically.Here, we report...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: December 2018Source: Interdisciplinary Neurosurgery, Volume 14Author(s): Saeed Oraee-Yazdani, Mahboube Kabiri, Maryam Oraee-Yazdani, Ali-Reza ZaliAbstractThere are few reports about abdominal pain due to shunt malposition which have been located in right lower quadrant. In this case, we reported a 17-years old boy with history of medulloblastoma surgery and shunt insertion who had severe abdominal pain especially in right upper quadrant without any history of fever, nausea and vomiting and any symptoms of ICP rising. Physical examination revealed a moderate tenderness on the right upper quadrant, but rebo...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
More News: Learning | Lung Transplant | Medical Ethics | Medulloblastoma | Universities & Medical Training