The Platinum 5 min in TCCC: Analysis of Junctional and Extremity Hemorrhage Scenarios with a Mathematical Model.

Conclusion: Thus the immediacy of intervention in terms of application of a tourniquet is clearly emphasized by the simulation, that is, the window of opportunity for a life-saving intervention, especially in a combat setting, is significantly smaller than the symbolic "platinum five minutes" might suggest. With respect to the 3-min window of opportunity identified in the simulations the effective application of these devices in a TCCC setting appears questionable. Given these observations, further research and development into solutions that allow the timely identification of a junctional bleeding problem and application of compression is necessary. PMID: 29547925 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research

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AbstractPurposeLMA® ProSeal ™ (pLMA) has been used as an alternative to tracheal tubes. It is unclear how many cases are required to achieve proficiency in performing pLMA insertion among novice residents. Therefore, we analyzed the learning curve of pLMA insertion using a cumulative sum (CUSUM) chart and assessed the effect s of learning.MethodsIn this single-center, prospective, observational study, we included 15 novice residents. Staff anesthesiologists recorded success or failure; insertion time; and incidences of bleeding or reflex including cough, hiccups, and limb movement. A successful pLMA insertion was...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionPatients with OI may not experience higher rates of perioperative complications compared with patients without OI syndromes.
Source: Clinical Autonomic Research - Category: Research Source Type: research
A 60-something man presented by EMS with 5 hours of fairly typical sounding substernal chest pain. Here is the EMS ECG:Obviously massive diffuse subendocardial ischemia, with profound STD and STE in aVROf course this pattern is most often seen from etoliogies other than ACS.  The ECG only tells you there is ischemia, not the etiology of it.Nevertheless, the clinical situation made other etiologies unlikely.EMS gave 324 mg aspirin and 3 sublingual NTG, which the patient stated reduced the substernal chest pain from an 8/10 to 4/10.Here is the ED ECG on arrival:Less STE/STDProvider's Clinical Impression: ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
We describe a 56-year-old woman with BMD who was scheduled for laparoscopic hysterectomy and bilateral adnexectomy under general anesthesia due to a mass in the uterus. The patient was diagnosed with BMD 20 years back and reported that during this period, she was able to walk slowly with help during her daily life. Additionally, she also had a history of hypertension since 4 years and type 2 diabetes mellitus since 2 years. Diagnosis: The patient was postmenopausal and presented with abnormal uterine bleeding and elevated CA125. Abdominal ultrasonography revealed diffuse enlargement of the uterus and hypoechoic internal...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Complex regional pain syndrome (CRPS) is a regional neuropathic pain syndrome. Excruciating pain often interferes with patients’ ability to function normally. Spinal cord stimulators (SCS) have been effective in treating pain along with signs of sympathetic overactivity in patients with CRPS. Implantation of SCS is a high-risk interventional procedure with the potential for serious bleeding and neurological consequences in the spine. Meticulous evaluation and careful optimization are needed in patients with bleeding disorders.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
In conclusion, these findings further support the idea of routine reflex molecular testing of uterine mesenchymal tumors with unusual clinical presentation or in case malignancy is suspected. Lastly, we suggestZC3H7B –BCOR rearranged high-grade endometrial stromal sarcoma might be considered as a tumor suitable for BCL6-targeted treatment.
Source: Virchows Archiv - Category: Pathology Source Type: research
Conclusion/Clinical Relevance: The case demonstrated that refractory AD could be managed with ITB in an emergency. PMID: 31815605 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Publication date: Available online 6 December 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Klaus Weber, Rüdiger Häcker, Jerold F. Hardisty, Stephen B. Harris, A. Wallace HayesAbstractBIA 10–2474 (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide) is a novel fatty acid amide hydrolase (FAAH) inhibitor developed by BIAL for the treatment of medical conditions which would benefit from enhanced levels of endogenous anandamide (AEA) such as pain disorders. During a Phase I clinical trial one subject died after receiving BIA 10–2474 and others displayed neurological signs....
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
AW Abstract BIA 10-2474 (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide) is a novel fatty acid amide hydrolase (FAAH) inhibitor developed by BIAL for the treatment of medical conditions which would benefit from enhanced levels of endogenous anandamide (AEA) such as pain disorders. During a Phase I clinical trial one subject died after receiving BIA 10-2474 and others displayed neurological signs. As part of series of papers presenting all the toxicology data available prior to the clinical trial we report here the nonclinical toxicology studies performed in cynomolgus monkeys. Maximum Tolera...
Source: Regulatory Toxicology and Pharmacology : RTP - Category: Toxicology Authors: Tags: Regul Toxicol Pharmacol Source Type: research
This study suggests thatH. axyridis adults are less affected than larvae by the frequent use of the defensive secretions in their stressful habitats.This article is protected by copyright. All rights reserved
Source: Insect Science - Category: Biology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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