Psychosis in "Cognitively Asymptomatic" Elderly Subjects is Associated With Neuritic Plaque Load, Not Neurofibrillary Tangles.

DISCUSSION: The load of NP may be an important substrate of psychosis in individuals who show no gross cognitive symptoms. PMID: 29553944 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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Publication date: Available online 10 December 2018Source: Progress in Biophysics and Molecular BiologyAuthor(s): E. Srinivasan, R. RajasekaranAbstractAmyotrophic lateral sclerosis (ALS) is a calamitous neurodegenerative disorder characterized by denervation of upper and lower motor neurons. Numerous hypotheses suggest that toxic protein misfolding and aggregation cause ALS, similar to that of other neurodegenerative diseases, such as Alzheimers and Parkinsons. Protruding causes of familial ALS are mutations in the gene encoding Cu/Zn superoxide dismutase-1 (SOD1), which decrease protein stability and endorse protein aggre...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Researchers from Johns Hopkins University have developed a new brain scan that uses radioactive 'tracer' molecules to 'light up' plaques that are responsible for cognitive decline in patients.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Dr Richard Isaacson on how the presence or lack of this gene may connote different risks and benefits.Medscape Neurology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Commentary Source Type: news
Publication date: Available online 11 December 2018Source: NeuroImage: ClinicalAuthor(s): Thomas D. Parker, Catherine F. Slattery, Keir X.X. Yong, Jennifer M. Nicholas, Ross W. Paterson, Alexander J.M. Foulkes, Ian B. Malone, David L. Thomas, David M. Cash, Sebastian J. Crutch, Nick C. Fox, Jonathan M. SchottAbstractThe most common presentation of early onset Alzheimer's disease (EOAD – defined as symptom onset
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 10 December 2018Source: NeuroImage: ClinicalAuthor(s): Arnd Sörensen, Ganna Blazhenets, Gerta Rücker, Florian Schiller, Philipp Tobias Meyer, Lars Frings, for the Alzheimer's Disease Neuroimaging InitiativeAbstractAimThe value of 18F-fluorodeoxyglucose (FDG) PET for the prognosis of conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is controversial. In the present work, the identification of cerebral metabolic patterns with significant prognostic value for conversion of MCI patients to AD is investigated with voxel-based Cox regression, which in contra...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
(CNN) — Tackling a tricky crossword or a challenging Sudoku puzzle will not fend off age-related mental decline, new research has shown. Scientists have, in recent years, argued that brain-training exercises, such as completing puzzles or learning another language, can reduce the risk of developing dementia. But that may not be the case after all, according to a team of Scottish researchers whose research was published in the BMJ. The study’s authors argue that such pursuits will not necessarily act as a preventative, but they could still provide a “higher cognitive point” from which to decline. The...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News aging Crossword Puzzle Local TV Source Type: news
Funding Opportunity RFA-NS-19-014 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports the development of PET radioligands that identify proteinopathies or pathological processes associated with the human biology of Alzheimer's disease related dementias (ADRDs). Activities supported under this FOA include, but are not limited to the in vitro screening of existing ligands against human ADRD brain tissue, medicinal chemistry support for development of new compounds and improvement of existing ligand specificity and selectivity, initial screening of ligands in appropriate animal m...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
This article cuts across a broad spectrum of diseases, but is focused on hormones, estrogen and something called the timing hypothesis.This proposition, that estrogen ’s effects on our minds and our bodies may depend heavily upon when we first start taking it, is a controversial and very big idea. It has a working nickname: “the timing hypothesis.”There are some very interesting hypotheses about the health of the brain and Alzheimer's in the article.If the timing hypothesis proves right and estrogen really does protect brains and hearts as long as we start it "at the right time", the calculation...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimer's disease estrogen facts about estrogen health life news women Source Type: blogs
(MedPage Today) -- News and commentary from the world of neurology and neuroscience
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
(McLean Hospital) McLean will lead a five-year study to investigate the use of electroconvulsive therapy (ECT) to treat severe agitation and aggression in people with Alzheimer's disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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