GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function

Conclusions Collectively, we provide here evidence that local GLP-1 release from α cells defines GPR142's beneficial effects on improving β cell function and mass, and we propose that GPR142 agonism may have translatable and durable efficacy for the treatment of type 2 diabetes. Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research