Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

Conclusions BA receptor activation can reverse obesity, NAFLD, and atherosclerosis by specific activation of FXR or TGR5. Our data suggest that, compared to activation of FXR or TGR5 only, dual activation of both FXR and TGR5 is a more attractive strategy for treatment of common metabolic disorders.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research