Oxysterol species: reliable markers of oxidative stress in diabetes mellitus

AbstractPurposeTo assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3 β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM).MethodsIn total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry andN,N-dimethylglycine derivatization. Correlations between oxysterols and clinical/biochemical characteristics of the diabetes patients, and factors affecting 7-Kchol and chol-triol, were also determined.ResultsPlasma 7-Kchol and chol-triol levels were significantly higher in type 1 and type 2 diabetes patients compared to healthy controls (P  
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

Related Links:

In conclusion, N-3 demonstrated antagonistic and non-additive actions with Sct. Moreover, the effects of the combined administration of Sct and N-3 were comparable to that of metformin; therefore, they might be considered as therapeutic alternatives in diabetes.
Source: Pathophysiology - Category: Pathology Source Type: research
In conclusion, DD is a major health problem worldwide. It is a significant CVD risk factor and should be treated according to current guidelines. The means today exist to normalize all quantitative, qualitative, and kinetic aberrations of DD, thereby reducing CVD risk. PMID: 29858856 [PubMed - in process]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
ConclusionsThere was a potential protective association of lipid-lowering medication (statin or fibrate) and statin use and the presence of NPDR in patients with type 2 diabetes in the JDCP study.
Source: Diabetology International - Category: Endocrinology Source Type: research
This study aimed at examining these subsets at different stages of diabetes progression and possible relationships with metabolic parameters.MethodsA total of 206 patients, 76 with type 1 and 130 with type 2 diabetes, were studied within the first year of diabetes diagnosis. In addition, 31 patients with type 1 and 73 with type 2 diabetes were examined at 5  years after diagnosis. Whole body insulin sensitivity was assessed by hyperinsulinemic–euglycemic clamps; insulin secretion by glucagon stimulation tests and white blood cells were analyzed by flow cytometry.ResultsThe percentage of peripheral CD8+ cells was...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
In conclusion, N-3 demonstrated antagonistic and non-additive actions with Sct. Moreover, the effects of the combined administration of Sct and N-3 were comparable to that of metformin; therefore, they might be considered as therapeutic alternatives in diabetes.
Source: Pathophysiology - Category: Pathology Source Type: research
In conclusion, N-3 demonstrated antagonistic and non-additive actions with Sct. Moreover, the effects of the combined administration of Sct and N-3 are comparable to that of metformin and might be considered for therapy in diabetes.
Source: Pathophysiology - Category: Pathology Source Type: research
ABSTRACT BackgroundWe assessed the frequency of short‐term oral corticosteroid use in adults with diabetes, and examined the incidence of fractures, venous thromboembolism (VTE) and hospitalization for sepsis after corticosteroid use. We also evaluated whether preventative medications mitigated adverse events. MethodsWe conducted a longitudinal study of 1,548,945 adults (ages 18‐64 years) who received healthcare coverage through a large national health insurer, years 2012‐2014. Incidence rate ratios (IRR) were calculated using conditional Poisson regression. ResultsShort‐term oral corticosteroids were used by 23.9%...
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Randomized controlled trials (RCTs) are considered the gold-standard study design for comparative effectiveness research, which involves directly comparing the effectiveness of one treatment to another. Despite their many benefits, RCTs have important limitations that can reduce their utility for certain types of comparative effectiveness research and limit the external validity of their findings. For this reason, real-world evidence—data about outcomes in actual patients who are receiving a treatment in a usual care setting—is gaining traction as a key source of evidence for comparative effectiveness research....
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Drugs and Medical Innovation chronic disease comparative effectiveness research efficacy-effectiveness gap health care innovation measuring care value randomized controlled trials real-world evidence Source Type: blogs
We examined the influence of transportation noise exposure over a 5-y period (1994–1998) on incident diabetes cases in a population-based prospective cohort study (n=380,738) of metropolitan Vancouver (BC) residents who were 45–85 y old, with 4-y of follow-up (1999–2002). Annual average transportation noise (Lden), air pollution [black carbon, particulate matter with aerodynamic diameter 10% of the population was of South Asian ethnicity, and nearly one-half of the sample lived in neighborhoods where>10% of the population was of Chinese ethnicity. All covariates were significantly associated with all o...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
ConclusionsLaparoscopic sleeve gastrectomy resulted in significant weight loss, comorbidity resolution as well as reduction in their insulin doses post-op. However, glycemic control does not seem to show significant improvement in these patients. Larger, more long-term studies are needed to reach a definite conclusion on this topic.
Source: Obesity Surgery - Category: Surgery Source Type: research
More News: Cholesterol | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Endocrinology | Smokers | Statin Therapy | Study