Oxysterol species: reliable markers of oxidative stress in diabetes mellitus

AbstractPurposeTo assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3 β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM).MethodsIn total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry andN,N-dimethylglycine derivatization. Correlations between oxysterols and clinical/biochemical characteristics of the diabetes patients, and factors affecting 7-Kchol and chol-triol, were also determined.ResultsPlasma 7-Kchol and chol-triol levels were significantly higher in type 1 and type 2 diabetes patients compared to healthy controls (P  
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

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Your Society are delighted to announce that we have awarded 10 Early Career Grants of£10,000 to early career members, to help fund their exciting and cutting edge research projects. Mr James Nicholson - Defining the early response to oncogenic Braf in pituitary progenitor/stem cells.Miss Emma McGlone - Statins and type 2 diabetes mellitus: is glucagon the missing link?Dr Nikolaos Nikolaou- Hepatic 5β-reductase (AKR1D1) activity as a regulator of adipose tissue biology and function; exploring theliver-adipose endocrine axis.Dr Nan Li - A novel animal model to explore the role of sex steroids on sex different...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
In conclusion, DD is a major health problem worldwide. It is a significant CVD risk factor and should be treated according to current guidelines. The means today exist to normalize all quantitative, qualitative, and kinetic aberrations of DD, thereby reducing CVD risk. PMID: 29858856 [PubMed - in process]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
ConclusionsThere was a potential protective association of lipid-lowering medication (statin or fibrate) and statin use and the presence of NPDR in patients with type 2 diabetes in the JDCP study.
Source: Diabetology International - Category: Endocrinology Source Type: research
ABSTRACT BackgroundWe assessed the frequency of short‐term oral corticosteroid use in adults with diabetes, and examined the incidence of fractures, venous thromboembolism (VTE) and hospitalization for sepsis after corticosteroid use. We also evaluated whether preventative medications mitigated adverse events. MethodsWe conducted a longitudinal study of 1,548,945 adults (ages 18‐64 years) who received healthcare coverage through a large national health insurer, years 2012‐2014. Incidence rate ratios (IRR) were calculated using conditional Poisson regression. ResultsShort‐term oral corticosteroids were used by 23.9%...
Source: Journal of Diabetes - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Randomized controlled trials (RCTs) are considered the gold-standard study design for comparative effectiveness research, which involves directly comparing the effectiveness of one treatment to another. Despite their many benefits, RCTs have important limitations that can reduce their utility for certain types of comparative effectiveness research and limit the external validity of their findings. For this reason, real-world evidence—data about outcomes in actual patients who are receiving a treatment in a usual care setting—is gaining traction as a key source of evidence for comparative effectiveness research....
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Drugs and Medical Innovation chronic disease comparative effectiveness research efficacy-effectiveness gap health care innovation measuring care value randomized controlled trials real-world evidence Source Type: blogs
CONCLUSION: The ODYSSEY DM-INSULIN study will provide information on the efficacy and safety of alirocumab in insulin-treated individuals with T1 or T2 DM who are at high CV risk and have hypercholesterolaemia not adequately controlled by the maximum tolerated statin therapy. PMID: 28347654 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
Statins are effective in the primary and secondary prevention of cardiovascular events in individuals with and without diabetes. Emerging evidence, however, suggests that statins might reduce insulin sensitivity and secretion in healthy population and in type 2 diabetes.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Original Article Source Type: research
Statins are effective in the primary and secondary prevention of cardiovascular events in individuals with and without diabetes. Emerging evidence, however, suggest that statins might reduce insulin sensitivity and secretion in healthy population as well as in type 2 diabetes.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Source Type: research
Abstract Cardiovascular disease is the leading cause of death among adults in the USA. Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) are known risk factors for cardiovascular disease. Despite the development of numerous effective anti-glycemic therapies, we have been unable to completely mitigate cardiovascular risk with glucose lowering alone, and prevention of cardiovascular disease in patients with diabetes is primarily achieved with the use of medications that address other risk factors such as anti-hypertensives or statins. Glucagon-like peptide-1 (GLP-1) is a key hormone in the pathophysiology of d...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
At my anti-aging clinic, I continue to wage war against what I call the “medical-industrial complex.” And I do it for one reason only – I care more about my patients than I do about profits. Big Pharma clearly takes the opposite view. And now it seems these pharmaceutical behemoths won’t be happy until every man, woman and child is popping anti-cholesterol pills. Researchers at Duke University recently issued a report recommending that even children and people as young as 30 should be on statins, if they have just slightly elevated cholesterol levels.1 And why wouldn’t researchers at Duke reco...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Heart Health Source Type: news
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