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More Cases Are Reported of Unusual Cancer Linked to Breast Implants

Women with breast implants have an increased risk of a type of lymphoma that can usually be cured by surgery alone — but not always.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Implants Breasts Allergan Inc Breast Cancer Non-Hodgkin's Lymphoma Mentor Worldwide LLC Food and Drug Administration American Society for Aesthetic Plastic Surgery Source Type: news

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Conclusion: This paper addresses the clinical implications of performing numerous CT examinations in patients with cancer, providing clinicians with information regarding methods to reduce risk factors in this patient population.Blood Purif 2018;46:56 –69
Source: Blood Purification - Category: Hematology Source Type: research
Conclusions: RDLs are frequently observed in high-risk patients for gastric cancer after eradication. M-NBI demonstrated significantly superior diagnostic efficacy with respect to RDL.Digestion 2018;98:48 –55
Source: Digestion - Category: Gastroenterology Source Type: research
This study showed that ESE-16 exposure leads to the aggregation of acidic vesicles, identified as lysosomes, not accompanied by an induction of autophagy. Therefore, ESE-16 disrupts normal endocytic vesicle maturation likely through the inhibition of the microtubule function.Pharmacology 2018;102:9 –16
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research
Preclinical and clinical studies have shown that viral-based immunotherapy has the potential to overcome resistance to immune checkpoint blockade (ICB) and to fill the unmet needs of many cancer patients. Poxviruses, such as modified vaccinia virus Ankara (MVA), have the potential as cancer immunotherapeutic agents. We recently showed that intratumoral (IT) delivery of inactivated modified vaccinia virus Ankara (iMVA) induces antitumor systemic immunity via the STING-mediated cytosolic DNA-sensing pathway and Batf3 –dependent CD103+/CD8+ dendritic cells (DCs).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Skin cancer is one of the most preventable forms of cancer. Roughly, 85% of skin cancer cases could be avoided by reducing UV exposure, especially during adolescence. We conducted a pilot study to evaluate sun safety behaviors in this age group, as well as, the effects of an innovative intervention in changing sun protection attitudes and behaviours. Methods: Participants were recruited from 8 secondary schools in Vancouver, BC. Participants were segregated into the control arm (N=38) or intervention arm (N=138).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
This study examines the incidence of rare cutaneous malignancies in a single institution as compared to publicly available SEER data. All patients presenting to the Johns Hopkins Health System from 2012 to 2017 with available demographics (n = 4,696,491) were considered, and those with a diagnosis of dermatofibrosarcoma protuberans (DFSP), Kaposi sarcoma (KS), Merkel cell carcinoma (MCC), mycosis fungoides/cutaneous T-cell lymphoma (CTCL), or sebaceous adenocarcinoma (SA) were stratified by race.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
This study was aimed to evaluate whether ROS could modulate Th2-type inflammation in keratinocytes. Allergen and non-allergen was tested in modulating Th2-type inflammation. Materials: For experiments, normal human epidermal keratinocytes (NHEKs) were treated with an allergen (HDM) and non-allergen (compound 48/80, C48/80) under the same condition.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Annabelle Y. Guo, PhD1, Indra Neil Sarkar, PhD1,3, Elizabeth S. Chen, PhD1,3,Joanna Walker, MD2, Paul Stey, PhD3, Wen Qing Li, PhD2, Eunyoung Cho, ScD2, Abrar A. Qureshi, MD21The Warren Alpert Medical School; 2Department of Dermatology; 3Center for Biomedical Informatics, Brown University, Providence, RI. Merkel Cell Carcinoma (MCC) is an aggressive malignant skin cancer with a high mortality rate. The effect of ultraviolet (UV) exposure on MCC patients long-term survival is not fully understood.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Background: The high keratinocyte carcinoma (KC) incidence in Western countries puts pressure on healthcare systems and urges to identify areas for improvement. Aim: To describe current KC care based on routinely collected data in primary and secondary care in the Netherlands. Methods: A retrospective cohort study using the Integrated Primary Care Information database and for specialist care the nationwide Netherlands Cancer Registry. In primary care 1736 records of patients with suspicious KC lesions were included (2009-2013).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Frequent use of sun-protection factor (SPF)>15 sunscreen is an important skin cancer prevention strategy, but little is known about users of SPF15 SPF versus
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
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