Bioactive dibenzofurans from the rattans of Bauhinia championii (Benth.) Benth.

Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Li-Ping Hua, Yu-Qin Zhang, Miao Ye, Wen Xu, Xiao-Ying Wang, Yan-Hui Fu, Wei Xu Two new dibenzofurans, bauhichamines A (1) and B (2), along with six known compounds (3-8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. (Fabaceae). The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparison of their data with those reported in the literatures. All new compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proliferative effects on synoviocytes in vitro. Compounds 1 and 2 exhibited significant inhibitory effects on the proliferation of synoviocytes with the IC50 values of 103.1 ± 1.8 and 146.4 ± 1.2 μM, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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The Editors-in-Chief have retracted this article [1]. Serious concerns have been raised about the data presented [2], and after careful consideration and additional investigation the Editors-in-Chief no longer have confidence in this article.
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Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
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