Cytotoxic and antimicrobial labdane and clerodane diterpenoids from Kaempferia elegans and Kaempferia pulchra

Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Pornsuda Chawengrum, Jutatip Boonsombat, Prasat Kittakoop, Chulabhorn Mahidol, Somsak Ruchirawat, Sanit Thongnest Three previously undescribed diterpenoids, propadanes A-C (1-3), together with seventeen known compounds (4-20), were isolated from the rhizomes of Kaempferia elegans and Kaempferia pulchra. The structures of the isolated compounds were elucidated through extensive analysis of spectroscopic data. The absolute configuration (12R) of propadane A (1) was established by CD analysis. (−)-Kolavelool (15) and (−)-2β-hydroxykolavelool (18) showed selective cytotoxic activity against the HL-60 cell line with IC50 values of 8.97 ± 0.66 and 9.58 ± 0.88 μg/mL, respectively. Anticopalic acid (5), anticopalol (10), and 8(17)-labden-15-ol (11) showed antimicrobial activity against the Gram positive bacterium, Bacillus cereus, with MIC values of 3.13, 6.25, and 6.25 μg/mL, respectively. Labdane-type diterpenoids were found to be common constituents in K. elegans, while clerodane-type diterpenoids were common in K. pulchra. This information could be used to establish their chemotaxonomy. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

Related Links:

Publication date: March 2020Source: Food Packaging and Shelf Life, Volume 23Author(s): Afsaneh Nouri, Mohammad Tavakkoli Yaraki, Aseman Lajevardi, Tayyebeh Rahimi, Marjan Tanzifi, Mohammad GhorbanpourAbstractIn the present research, biodegradable κ- carrageenan (KC) nanocomposite film was prepared by incorporation nanoclay, 1–3% v/v of Zataria multiflora plant extract (ZME) and glycerol as a plasticizer via two different procedures. The nanocomposite films were characterized by their optical, microstructural, mechanical and thermal as well as antimicrobial properties against S. aureus, B.cereus, E.coli, and P. ...
Source: Food Packaging and Shelf Life - Category: Food Science Source Type: research
Publication date: Available online 14 November 2019Source: Food ChemistryAuthor(s): Selina Brighina, Cristina Restuccia, Elena Arena, Rosa Palmeri, Biagio FallicoAbstractThe antibacterial activities of the dicarbonyl compounds glyoxal (GO), methylglyoxal (MGO), 3-deoxyglucosone (3-DG) were assessed against Gram-positive and Gram-negative pathogenic and food spoilage bacteria, both in agarised and liquid assay system. The kinetics of dicarbonyls’ degradation at different antimicrobial assay conditions were studied, to determine the possible interference of the nutrient medium.In agarised assay system, GO and MGO exhib...
Source: Food Chemistry - Category: Food Science Source Type: research
Abstract Bacillus cereus CR4 from the flocs of activated sludge was found to produce an extracellular bioflocculant, which was characterized as amyloid protein and demonstrated to have potential application in microalgae recovery. Cell surface amyloid production was demonstrated by fluorescence, confocal and scanning electron microscopy. Birefringence, spectral shift assay, TEM, FTIR and CD spectra confirmed the amyloid nature of the purified protein that demonstrated flocculation. The gene for amyloid protein of B. cereus CR4 was found to be related to tasA gene of amyloid protein produced by Bacillus subtil...
Source: Biotechnology Letters - Category: Biotechnology Authors: Tags: Biotechnol Lett Source Type: research
This study explored the bacterial diversity of 64 spoiled custard cream desserts manufactured by 2 French companies. B. cereus group bacteria, coagulase negative Staphylococcus, Enterococcus and Leuconostoc spp. were isolated from spoiled products. Thirty-one bacterial isolates representative of the main spoilage species were tested for their spoilage abilities. Significant growth and pH decrease were observed regardless of species. While off-odours were detected with B. cereus group and staphylococci, yoghurt odours were detected with Enterococcus spp. and Leuconostoc spp. B. cereus group bacteria produced various esters ...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
An infected aneurysm of the thoracic aorta is a rare clinical condition with significant morbidity and mortality. Patients with fast-growing aortic aneurysms show a high incidence of rupture. Gram-positive org...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Publication date: Available online 9 November 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Aqsa Habib, Muhammad Adnan Iqbal, Haq Nawaz Bhatti, Amna Kamal, Shagufta KamalAbstractA new series of N-Heterocyclic carbene based ligands and their silver(I) complexes was obtained and tested in vitro on three bacterial strains (Bacillus subtillis, Bacillus cereus and Macrococcus brunensis) to assess their antibacterial potential. Hemolytic and thrombolytic activities of ligands and complexes on normal mouse erythrocytes were also assessed. In vitro antibacterial study of ligands and complexes revealed that the complexes...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
This study aimed to evaluate the safety of raw vegetable products present on the German market regarding toxin-producing Bacillus cereus sensu lato (s.l.) group bacteria.
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31703147 [PubMed - as supplied by publisher]
Source: Biotechnology Journal - Category: Biotechnology Authors: Tags: Biotechnol J Source Type: research
The objectives of this research were to screen anti-quorum sensing activity of phyllosphere bacteria and quantify their antibiofilm activity against biofilm forming bacteria (Bacillus cereus, Staphylococcus aureu...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
In this study, silver nanoparticles (Ag NPs) were synthesized using reishi mushroom (Ganoderma lucidum) extract. Different analytical techniques including X-ray Photoelectron Spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM), UV–vis spectroscopy, and Fourier Transform Infrared Spectrophotometer (FTIR) were used for the characterization of Ag NPs. Uv-Vis spectrum exhibited a broad absorption peak between 400-460 nm which indicates the existence of Ag NPs. TEM images showed Ag NPs are spherical with a diameter range of 15-22 nm. In addition, it is shown that Ag NPs form a...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
More News: Bacillus Cereus