Oleanane triterpenoids from the Algerian Salvia phlomoides

Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Lamia Benniou, Moses K. Langat, Dulcie A. Mulholland, Fadila Benayache, Samir Benayache Three previously unreported triterpenoids 2α,3β,11α-trihydroxyolean-18-ene 1, 3β-acetoxy,2α,11α- dihydroxyolean-18-ene 2 and 2α-acetoxy,3β,11α-dihydroxyolean-18-ene 3 were isolated from the chloroform extract of aerial parts (leaves and flowers) of Salvia phlomoides collected from the Constantine region in the east of Algeria. Structures were determined using NMR spectroscopy and HR-ESI mass spectrometry. Compounds 1, 2 and 3 were tested against the NCI panel of human tumour cell lines at a single dose of 10 μM. Compound 2 was the most active showing a 38% growth inhibition against the leukaemia RPMI-8226 line. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research