Healing the Patient of Tomorrow

Products on well-understood commercialization tracks often take an incremental approach rather than trying to create paradigm-shifting technologies. In this blog, I’ll take a look at medical devices that are on a commercialization track to heal the patient of tomorrow in a way that is substantially better than previous offerings. They are generally broken into three broad categories based on their advantages over existing medical devices: either healing the patient at home, fixing issues with existing devices, or creating non-invasive diagnostic tools. Connected Home Use Devices Connected home-use devices allow a patient to undergo most of their recovery or treatment at home. This increases opportunities for rest and connects unedited patient data directly to the physician rather than getting a version of the story from the patient. In most cases, patients receive more physician attention than they would from visiting clinics periodically. The medical practitioner has information access on an instant feedback loop even when the patient is at home. Home-use therapy that connects directly to healthcare providers is a fantastic example of modern therapeutics and has been explored a number of times in digital health resources. Don't miss New England's largest event for medtech professionals! Get 20% off registration for the BIOMEDevice Boston Conference with promo code "MDDI". Patients using these devices can take part in their own care, where appropriate. Usage a...
Source: MDDI - Category: Medical Devices Authors: Tags: Design Source Type: news

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Authors: Lee HJ, Han YM, An JM, Kang EA, Park YJ, Cha JY, Hahm KB Abstract INTRODUCTION: Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro-inflammatory mediators, whereas n-3 PUFAs possess anti-inflammatory properties. Therefore, interest in the cancer-preventive effect of n-3 PUFAs is increasing. Areas covered: We have observed significant reductions of gastrointestinal (GI) tumorigenesis in the Fat-1 transgenic mouse as evide...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
was established in 2004 and consents patients in Wales, UK with a known or suspected cancer diagnosis to donate biosamples for future research. The resource is open access to all researchers working in cancer research, regardless of geographic location or employment sector. To December 2017, just over 13,500 patients have donated samples across a variety of tumour types. Tumour and adjacent normal tissue and blood samples are routinely collected, stored and processed to standardised protocols. Bespoke collections for unique samples such as urine or ascites are also available. Pathology data, clinical data including treatm...
Source: Open Journal of Bioresources - Category: Biotechnology Source Type: research
Martin K. Stiles, Prashanthan Sanders, Dennis H. Lau
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 17 September 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Ria Biswas, Nilkanta Chowdhury, Ranjita Mukherjee, Angshuman BagchiAbstractThe interaction of the proteins, tumor necrosis factor receptor-associated factor6 (TRAF6) and Basigin (CD147), is known to be associated with the over-expression of matrix metalloproteinases (MMPs) in melanoma cells. MMPs are known to be responsible for melanoma metastasis. Hence, TRAF6-Basigin complex can act as a potential therapeutic target. In previous studies, amino acid residues Lys340, Lys 384, Glu417 and Glu511 of TRAF6 were ide...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Authors: Campione E, Ventura A, Diluvio L, Mazzeo M, Mazzilli S, Garofalo V, Di Prete M, Bianchi L Abstract INTRODUCTION: Actinic keratosis (AK) is considered as a superficial squamous cell carcinoma (SCC). A central role in the pathogenesis is played by chronic sun exposure. UVB causes direct damage to DNA, producing pyrimidine dimers, and suppressing the protective role of p53. The stepwise progression of AK, with an increased expression of anti-apoptotic Bcl-2, favors the progression to SCC. Moreover, the dermal response characterized by inflammation and mediated by prostaglandins is a critical component of tumo...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: 20 December 2018Source: Sensors and Actuators B: Chemical, Volume 277Author(s): Xiangge Tian, Zhenhao Tian, Yan Wang, Jie Hou, Lei Feng, Liang Song, Jingnan Cui, Xiaokui Huo, Xinyu Zhao, Dayong Zhou, Chao Wang, Chengpeng Sun, Jing Ning, Xiaochi MaAbstractCisplatin is a widely used anti-cancer drug in clinic, while many cancer cells gradually exhibited serious cisplatin resistance recently, which resulted in reducing its clinical effects. Glutathione transferases (GSTs) as an extensive expressed metabolic enzyme in human, plays a significant role in the metabolism of cisplatin. Thus, sensitively and accura...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Four European patients developed breast cancer after receiving organs from the same donor, a case report explains.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Conclusions: Significant differences emerged between the stakeholder groups in several ROR scenarios. Policies that are acceptable to participants, researchers and IRBs, and that ensure human subject protections and facilitate research are needed.Public Health Genomics
Source: Public Health Genomics - Category: Genetics & Stem Cells Source Type: research
ConclusionsThe patients with high-risk prostate cancer can develop late recurrence and require long-term follow-up. Identifying patients with higher PSA levels and lymph node invasion has an important predictive role in the first year after surgery. The association between RLP and BR warrants further assessment.ResumenObjetivoDeterminar factores predictivos de recidiva bioquímica (RB) temprana, intermedia y tardía después de prostatectomía radical mínimamente invasiva en pacientes con cáncer de próstata localizado.Material y métodosSe incluyeron 6.195 pacientes con c&...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
In American cancer clinics, ringing a bell is now a commonplace celebration for patients who have completed chemotherapy or radiotherapy. But the cathartic ritual leaves some patients feeling very left out.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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