Healing the Patient of Tomorrow

Products on well-understood commercialization tracks often take an incremental approach rather than trying to create paradigm-shifting technologies. In this blog, I’ll take a look at medical devices that are on a commercialization track to heal the patient of tomorrow in a way that is substantially better than previous offerings. They are generally broken into three broad categories based on their advantages over existing medical devices: either healing the patient at home, fixing issues with existing devices, or creating non-invasive diagnostic tools. Connected Home Use Devices Connected home-use devices allow a patient to undergo most of their recovery or treatment at home. This increases opportunities for rest and connects unedited patient data directly to the physician rather than getting a version of the story from the patient. In most cases, patients receive more physician attention than they would from visiting clinics periodically. The medical practitioner has information access on an instant feedback loop even when the patient is at home. Home-use therapy that connects directly to healthcare providers is a fantastic example of modern therapeutics and has been explored a number of times in digital health resources. Don't miss New England's largest event for medtech professionals! Get 20% off registration for the BIOMEDevice Boston Conference with promo code "MDDI". Patients using these devices can take part in their own care, where appropriate. Usage a...
Source: MDDI - Category: Medical Devices Authors: Tags: Design Source Type: news

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Publication date: Available online 16 November 2018Source: Trends in Food Science &TechnologyAuthor(s): Rukiye BOZBULUT, Nevin SANLİERAbstractDiabetes is a global burden and a significant public health problem all over the world with an increasing incidence. One of the important factors to prevent and treat diabetes is nutritional therapy. Epidemiological and short-term interventional studies emphasise the association between higher fibre intake and improvements in lipid profile as well as fasting and postprandial glycaemic control. Soluble fibres are more effective for management of diabetes, obesity, dyslipidaemia, ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
PANCREATIC cancer has the highest death rates of the all the common cancers. There is no specific cause, but there are certain things that increase the risk. These risk factors may determine if you are at risk of developing the deadly disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Iordache SD, Goldberg N, Paz L, Peylan J, Hur RB, Steinmetz A Abstract To investigate exposure to radiation we identified a cohort of 312 patients who underwent standardized CT of an upper limb within a three years period. The effective dose per dose length product coefficient was used to calculate the effective doses of radiation. Mean effective doses were as follows: shoulder CT, 10.83 (SD 6.36) mSv; wrist CT, 0.15 (SD 0.07) mSv; elbow CT performed with the arm above the head, 0.21 (SD 0.11) mSv and with the arm adjacent to the torso, 13.1 (SD 10.8) mSv. The corresponding lifetime attributable risk of ca...
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
Abstract Self-hardening calcium phosphate cements present ideal bone tissue substitutes from the standpoints of bioactivity and biocompatibility, yet they suffer from (a) weak mechanical properties, (b) negligible osteoinduction without the use of exogenous growth factors, and (c) a lack of intrinsic antibacterial activity. Here we attempt to improve on these deficiencies by studying the properties of self-setting Fe-doped bone-integrative cements containing two different concentrations of the dopant: 0.49 and 1.09 wt% Fe. The hardening process, which involved the transformation of Fe-doped β-tricalcium pho...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Studies on the interaction of mononuclear metal(II) complexes of amino‑naphthoquinone with bio-macromolecules. Mater Sci Eng C Mater Biol Appl. 2019 Jan 01;94:778-787 Authors: Kosiha A, Lo KM, Parthiban C, Elango KP Abstract Three metal(II) complexes [CoLCl2], [CuLCl2] and [ZnL2Cl2] {L = 2‑chloro‑3‑((3‑dimethylamino)propylamino)naphthalene‑1,4‑dione} have been synthesized and characterized using analytical, thermal and spectral techniques (FT-IR, UV-Vis, ESR and ESI-MS). The structure of the L has been confirmed by single crystal XRD study. The complexes show good binding propensity ...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Abstract Redox-active compounds such as copper-phenanthroline are known as artificial/chemical nucleases with a great impact and potential for their applications as metallotherapeutics. In that vein, the mononuclear copper(II) complexes [Cu(L)2(bipy)] (1), [Cu(L)2(bipy)(H2O)] (2) and [Cu(L)2(phen)(H2O)] (3), where L = 2-thiophene carboxylate, bipy = 2,2΄-bipyridine and phen = 1,10-phenanthroline, have been prepared and pharmacochemically studied, while the crystal structure of 1 is also reported. All the tested complexes preferably bind to CT-DNA via minor groove as resulted from UV spectroscopy studi...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Abstract Heparan sulfate (HS) is a kind of natural polysaccharides with good biocompatibility. And as drug carriers, it has some advantages compared to heparin. However, the preparation of HS is cumbersome and difficult, which limits its application in drug delivery. Here, we use modern separation technique combined with chromatography to establish a new preparation method of HS. The molecular weight and degree of dispersion of HS were (1.03 × 104 ± 107) kDa and 1.106, respectively. HS also showed low anticoagulation activity in comparison with heparin. Subsequently, novel redox-sensitive he...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Authors: Supuran CT Abstract INTRODUCTION: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2.1.1), CA IX and XII, involved in complex processes connected to tumorigenesis (pH regulation, metabolism, invasion and dissemination of the tumor). The biochemical rationale behind these processes is orchestrated by the transcription factor hypoxia inducible factor 1 (HIF-1). Areas covered. CA IX and XII have been validated as antitumor/antimetastatic drug targets and may be used for imaging hypoxic tumors. Many CA inhibitors (CAIs) selectively inhibit two isoforms belonging to the sulfonamide, coumarin and sul...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Yaroslav R. Efremov, Anastasia S. Proskurina, Ekaterina A. Potter, Evgenia V. Dolgova, Oksana V. Efremova, Oleg S. Taranov, Aleksandr A. Ostanin, Elena R. Chernykh, Nikolay A. Kolchanov, Sergey S. Bogachev
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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