Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung

Publication date: April 2018 Source:The Annals of Thoracic Surgery, Volume 105, Issue 4 Author(s): Daniel C. Wiener, Carlos E. Bravo-Iñiguez, Vincent Trien-Vihn Ho, Xiaohua Qian, Michael T. Jaklitsch Donor T cells after allogeneic hematopoietic cell transplantation can give rise to the graft-versus-tumor (GVT) effect in hematologic malignancies. GVT effect has been reported previously to cause regression of some solid tumors. However, none have reported a documented case of GVT effect leading to complete resolution of adenocarcinoma of the lung. Here, we present the case of complete regression of a pathologically proven adenocarcinoma of the lung in a patient undergoing myeloablative-matched unrelated donor peripheral blood stem cell transplantation for the treatment of acute myelogenous leukemia.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research