Megalin/cubilin has a minor  role in the proximal tubular cell uptake of filtered albumin

The claim by Weyer et  al.1 that the megalin/cubilin complex is the only way filtered albumin may enter the proximal tubule cell (PTC) has now been shown to be incorrect. The low capacity of the megalin/cubilin complex for albumin implies that the glomerular sieving coefficient (GSC) of albumin is very low (

Source: Kidney International - March 21, 2018 Category: Urology & Nephrology Authors: Wayne D. Comper Tags: Letter to the Editor Source Type: research