Quadruple Dosing of Doripenem Is Safe in Patients With CFQuadruple Dosing of Doripenem Is Safe in Patients With CF

High doses of the antibiotic doripenem are safe to use in patients with cystic fibrosis suffering from acute respiratory infection. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

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Conditions:   Cystic Fibrosis;   Bronchiectasis Intervention:   Other: Comprehensive Respiratory Physiotherapy Sponsor:   Bezmialem Vakif University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Brennan GT, Saif MW Abstract Pancreatic enzyme replacement therapy is safe and effective at treating pancreatic exocrine insufficiency. There are multiple causes of pancreatic exocrine insufficiency including chronic pancreatitis, cystic fibrosis and pancreatic cancer. Testing fecal elastase-1 level is useful for the diagnosis of pancreatic exocrine insufficiency. Starting doses of pancreatic enzyme replacement therapy should be at least 30-40,000 IU with each meal and 15-20,000 IU with snacks. pancreatic enzyme replacement therapy should be taken in divided doses throughout meals. Patients who do not resp...
Source: Journal of the Pancreas - Category: Gastroenterology Tags: JOP Source Type: research
We examined the association between the 8.1 ancestral haplotype and delayed colonization in Cystic Fibrosis, postulating that downregulation ofRNF5 expression is the likely causal mechanism. Our study provides insights into the genetic architecture of the MHC region and pinpoints disease associations that are due to differential expression of HLA genes and non-HLA genes.
Source: eLife - Category: Biomedical Science Tags: Computational and Systems Biology Genetics and Genomics Source Type: research
Streptococcus pseudopneumoniae, first described in 2004, belongs to the “mitis group” within the viridans group of streptococci (VGS) [1]. An extremely high level of similarity, especially noted for Streptococcus pneumoniae, Streptococcus mitis, and S. pseudopneumoniae, characterizes the species of the mitis group. The identification of S. pseudopneumoniae remains t herefore challenging [1–3].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research
Mutations in the Cystic Fibrosis (CF) gene alter the structure and function of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) channel, impairing the flow of chloride and bicarbonate ions across epithelia in many organs of the body [1]. CFTR shares an overall architecture that is conserved in ATP-binding cassette (ABC) transporters and consists of two transmembrane domains (TMD1 and TMD2), two nucleotide-binding domains (NBD1 and NBD2), and a unique regulatory (R)-region (Fig. 1A) [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
CONCLUSIONS: The cut-offs used for caeruloplasmin, 24-hour urinary copper and hepatic copper for diagnosing Wilson's disease are method-dependent and require validation in the population in which such index tests are going to be used. Binary cut-offs and use of single-test strategies to rule Wilson's disease in or out is not supported by the evidence in this review. There is insufficient evidence to inform testing in specific subgroups, defined by age, ethnicity or clinical subgroups. PMID: 31743430 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Dietary intervention in cystic fibrosis (CF) has historically focused on high-energy diets to address malnutrition, with little attention on diet quality. With increased survival, CF complications such as impaired glucose tolerance (IGT) and cystic fibrosis related diabetes (CFRD) have increased in prevalence. In the absence of consensus on the management of IGT, the role of dietary intake, specifically carbohydrate quality, requires consideration.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Conclusions: The pattern of airway colonisation in the Indian setting is different from the Caucasian population, and P. aeruginosa and Burkholderia cepacia complex appear early. Colonisation with P. aeruginosa benefits from therapy. In case of infection, care must be taken while initiating empiric therapy. It should be based on local antibiograms to prevent the emergence of resistant microbes.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Condition:   Cystic Fibrosis Interventions:   Dietary Supplement: Resveratrol;   Dietary Supplement: NR;   Dietary Supplement: Placebo Sponsor:   Virginia Commonwealth University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
slash;iby N Abstract Background: Pulmonary infection with the multidrug-resistant Mycobacterium abscessus complex (MABSC) is difficult to treat in individuals with cystic fibrosis (CF). MABSC grows as biofilm aggregates in CF lungs, which is known to have anaerobic niches. How aggregation and anoxic conditions affect antibiotic tolerance is not well understood.Objectives: We sought to determine whether disaggregation and oxygen availability sensitizes MABSC isolates to recommended antibiotics.Methods: We tested susceptibility of the following antibiotics amikacin, azithromycin, cefoxitin, ciprofloxacin, clarithrom...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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