Gray matter volume differences between affective and non-affective first episode psychosis: A review of Magnetic Resonance Imaging studies

Affective and non-affective psychoses are two common psychiatric illnesses characterized by both overlapping and unique brain abnormalities (Hibar et  al., 2017; van Erp et al., 2016). Specifically, affective psychoses, and in particular bipolar disorder (BD), have been associated with gray matter (GM) reductions in prefrontal and paralimbic regions, including anterior cingulate cortex and insula, compared to healthy controls (Ellison-Wright a nd Bullmore, 2010). In contrast, ventricular enlargement and diffuse fronto-temporal GM reductions seem to characterize non-affective psychoses, especially schizophrenia (SCZ) (Berger et al., 2017; Chung et al., 2017; Wright et al., 2000).

Source: Journal of Affective Disorders - March 17, 2018 Category: Neurology Authors: A. Calvo, G. Delvecchio, A.C. Altamura, J.C. Soares, P. Brambilla Tags: Review article Source Type: research