Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice.

Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice. Neurochem Res. 2018 Mar 14;: Authors: Nieoczym D, Socała K, Wlaź P Abstract Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervous system-related processes, i.e., pain, anxiety and depression, was proved in experimental studies. UA also revealed anticonvulsant properties in animal models of epilepsy and seizures. The aim of the present study was to investigate the influence of UA on seizure thresholds in three acute seizure models in mice, i.e., the 6 Hz-induced psychomotor seizure threshold test, the maximal electroshock threshold (MEST) test and the timed intravenous pentylenetetrazole (iv PTZ) infusion test. We also examined its effect on the muscular strength (assessed in the grip strength test) and motor coordination (estimated in the chimney test) in mice. UA at doses of 50 and 100 mg/kg significantly increased the seizure thresholds in the 6 Hz and MEST tests. The studied compound did not influence the seizure thresholds in the iv PTZ test. Moreover, UA did not affect the motor coordination and muscular strength in mice. UA displays only a weak anticonvulsant potential which is...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

Related Links:

(Natural News) According to a study published in The BMJ, treating epilepsy with a group of drugs known as gabapentinoids is linked to a dangerously increased risk in suicidal behavior in young patients. Gabapentinoids are also commonly used to treat nerve pain and anxiety disorders. This revelation is exceptionally worrying when you take into account the fact that...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
e;dek J, Rokyta R Abstract Neurostimulation methods are used in the treatment of chronic pain, although mainly for pharmacology resistant pain. Transcranial Direct Current Stimulation (tDCS) is a non-invasive neurostimulation method using low direct current (0.029-0.08 mA/cm2) applied to a cathode and anode, which directly stimulates the cranial surface. The applied current causes the most significant changes directly under the electrodes: the cathode reduces the excitability of cortical neurons, whereas the anode increases excitability. The effect of stimulation usually lasts a few hours up to a few days. We obse...
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - Category: Geriatrics Source Type: research
__________ Just a heads-up about a great event later this week in Dublin, Ireland, for those working on virtual and augmented reality and healthcare innovation. When: Thu Dec 5, 2019 8:00 am — Fri Dec 6, 2019 5:00 pm. Where: Davenport Hotel Featured sessions include: Day 1 – Thursday, December 5th, 2019 9:00am‑9:30am Introductions, Welcome and Setting The Stage Robert Fine, Executive Director, International Virtual Reality and Healthcare Association (IVRHA) 9:30am-10:30am Keynote Presentation:  Virtual Reality and Healthcare: The Past, The Present and The Future Dr. Walter Gree...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology augmented reality Dublin healthcare healthcare innovation virtual-reality Source Type: blogs
Cannabidiol (CBD) oil and other products containing CBD are being touted as a natural, organic remedy for a wide range of women’s health concerns. Sellers of these products make many claims: CBD has calming effects on sleep, mood, and anxiety; eases hot flashes and improves bone density by balancing hormonal changes of menopause; and has anti-inflammatory properties that clear skin, cure acne, and calm rosacea. It’s promoted for PMS symptoms like bloating and mood swings. And CBD-infused lubricants claim to boost arousal and enjoyment of sex. So, how much of this is true? First, what is CBD? CBD is a major ingr...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Marijuana Women's Health Source Type: blogs
Marijuana is more mainstream than it’s ever been. A growing number of states are legalizing it medicinally and recreationally; millions of people are vaping products that contain the compound THC (potentially to the detriment of their health); and non-psychoactive CBD is in everything from beauty products to seltzer water. This spring, Google searches for CBD exceeded searches for buzzy health topics like acupuncture, apple cider vinegar and meditation, according to a recent JAMA Network Open analysis. The problem: Even though many consumers turn to cannabis compounds, known as cannabinoids, to soothe issues like dep...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology Source Type: news
AbstractBackgroundPeople with Alzheimer's disease (AD) often have multimorbidity and take multiple medicines. Yet few studies have examined medicine utilization for comorbidities comparing people with and without AD.ObjectiveThe aim was to investigate the patterns of medication use for comorbidities in people with and without AD.MethodsAn Australian population ‐based study was conducted using the Pharmaceutical Benefits Scheme 10% sample of pharmacy claims data.People with ADwere defined as those dispensed medicines for dementia (cholinesterase inhibitors, memantine, or risperidone for behavioral and psychological sympto...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research
ConclusionsThis study provides an important stepping stone in the understanding of demographic and seizure factors, personality domains, abnormal illness behaviors, and psychiatric comorbidity in the South African population with PNES. The study also reported on a cutoff score of 12 on the BAI-PC predicting PNES with 80% sensitivity and 89% specificity in a private hospital sample.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
CONCLUSIONS: This study provides an important stepping stone in the understanding of demographic and seizure factors, personality domains, abnormal illness behaviors, and psychiatric comorbidity in the South African population with PNES. The study also reported on a cutoff score of 12 on the BAI-PC predicting PNES with 80% sensitivity and 89% specificity in a private hospital sample. PMID: 31382179 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
This study explored the acceptability and feasibility of an MBCT intervention for this group. The data suggests that this intervention could be potentially useful in improving the mental health of this population, and includes suggestions for making the intervention culturally relevant.
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
More News: Antidoxidants | Anxiety | Brain | Depression | Diets | Epilepsy | Neurology | Neuroscience | Nutrition | Pain | Study